PMID- 18219622
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20211020
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 30
IP  - 2
DP  - 2009 Feb
TI  - Sex differences in brain activation to anticipated and experienced pain in the 
      medial prefrontal cortex.
PG  - 689-98
LID - 10.1002/hbm.20536 [doi]
AB  - Previous studies on sex differences in neural responses to noxious stimuli 
      yielded mixed results. Both increased and decreased brain activation in several 
      brain areas in women as compared to men has been reported. The current 
      event-related functional magnetic resonance imaging study used a parametric 
      design with different levels of the intensity of electrical stimulation in order 
      to investigate sex differences in brain activation during pain processing. Four 
      intensity levels, which were determined individually according to subjective 
      ratings, ranging from stimulation below the stimulus detection threshold to 
      moderately painful stimuli, were applied. Females experienced mild and moderate 
      pain at lower stimulus intensity than males. Pronounced sex differences in brain 
      activation were found in response to stimulation below the detection threshold 
      and for the most intense pain stimuli in the medial prefrontal cortex (MPFC). 
      Under both the conditions, women showed stronger activation in a region of the 
      pregenual MPFC, which has been implicated in introspective, self-focused 
      information processing. The results suggest that women, as compared to men, show 
      increased self-related attention during anticipation of pain and in response to 
      intense pain.
FAU - Straube, Thomas
AU  - Straube T
AD  - Department of Biological and Clinical Psychology, Friedrich-Schiller-University 
      of Jena, Jena, Germany. straube@biopsy.uni-jena.de
FAU - Schmidt, Stephanie
AU  - Schmidt S
FAU - Weiss, Thomas
AU  - Weiss T
FAU - Mentzel, Hans-Joachim
AU  - Mentzel HJ
FAU - Miltner, Wolfgang H R
AU  - Miltner WH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/anatomy & histology/physiology
MH  - Electric Stimulation/adverse effects
MH  - Fear/*physiology
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/anatomy & histology/physiology
MH  - Neuropsychological Tests
MH  - Pain/*physiopathology/*psychology
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - Prefrontal Cortex/anatomy & histology/*physiology
MH  - *Sex Characteristics
MH  - Young Adult
PMC - PMC6870921
EDAT- 2008/01/26 09:00
MHDA- 2009/04/10 09:00
PMCR- 2008/01/24
CRDT- 2008/01/26 09:00
PHST- 2008/01/26 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
PHST- 2008/01/26 09:00 [entrez]
PHST- 2008/01/24 00:00 [pmc-release]
AID - HBM20536 [pii]
AID - 10.1002/hbm.20536 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2009 Feb;30(2):689-98. doi: 10.1002/hbm.20536.