PMID- 18219825
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20190902
IS  - 0070-217X (Print)
IS  - 0070-217X (Linking)
VI  - 318
DP  - 2008
TI  - Neuromyelitis optica: clinical syndrome and the NMO-IgG autoantibody marker.
PG  - 343-56
AB  - Neuromyelitis optica (NMO) is a severe demyelinating disease of the CNS that 
      preferentially affects the optic nerves and spinal cord, tends to relapse, and 
      results in early permanent disability for most affected patients. A new 
      autoantibody marker called neuromyelitis optica immunoglobulin G (NMO-IgG), which 
      targets the water channel protein aquaporin-4, is highly specific for NMO. The 
      marker has demonstrated that the NMO spectrum of disorders is wider than 
      previously known and includes some patients with single-episode or recurrent 
      longitudinally extensive myelitis, recurrent isolated optic neuritis, Asian 
      optic-spinal multiple sclerosis, and patients with co-existing systemic 
      autoimmune diseases such as lupus erythematosus or Sjogren's syndrome. We review 
      the place of NMO within the nosology of CNS demyelinating diseases, the discovery 
      of NMO-IgG and its impact on the definition of NMO and its spectrum, implications 
      for understanding NMO pathogenesis, and informing treatment decisions.
FAU - Weinshenker, B G
AU  - Weinshenker BG
AD  - Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, 
      Rochester, MN 55901, USA. weinb@mayo.edu
FAU - Wingerchuk, D M
AU  - Wingerchuk DM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Curr Top Microbiol Immunol
JT  - Current topics in microbiology and immunology
JID - 0110513
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Autoantibodies/*blood
MH  - Biomarkers/*blood
MH  - Humans
MH  - Immunoglobulin G/*blood/immunology
MH  - Mice
MH  - Neuromyelitis Optica/immunology/*physiopathology
RF  - 39
EDAT- 2008/01/29 09:00
MHDA- 2008/02/26 09:00
CRDT- 2008/01/29 09:00
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - 10.1007/978-3-540-73677-6_14 [doi]
PST - ppublish
SO  - Curr Top Microbiol Immunol. 2008;318:343-56. doi: 10.1007/978-3-540-73677-6_14.