PMID- 18221424
OWN - NLM
STAT- MEDLINE
DCOM- 20080806
LR  - 20211020
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 9
IP  - 2
DP  - 2008 Apr
TI  - Maternal diet during pregnancy and islet autoimmunity in offspring.
PG  - 135-41
LID - 10.1111/j.1399-5448.2007.00311.x [doi]
AB  - BACKGROUND: Recent studies on the etiology of type 1 diabetes mellitus (T1DM) 
      suggest that the components of the infant diet are associated with islet 
      autoimmunity (IA), a precursor of T1DM. The role of prenatal nutritional 
      exposures has not been thoroughly investigated. METHODS: The Diabetes 
      Autoimmunity Study in the Young has enrolled newborns from 1993 to 2004 at 
      increased risk for T1DM based on human leukocyte antigen (HLA) genotype and 
      family history of T1DM. The child is tested for islet autoantibodies at 9 and 15 
      months, 2 yr, and annually thereafter. We conducted a cohort study of 642 
      subjects for whom a Willett food frequency questionnaire for the mother's third 
      trimester diet was completed. A case is defined as a subject who tests positive 
      for islet autoantibodies at two consecutive blood draws and is still positive (or 
      diabetic) at last follow-up (n = 27). Maternal consumption frequencies of 
      potatoes, other root vegetables, gluten-containing foods, non-gluten cereal 
      grains, cow's milk and cow's milk products, fruits, vegetables, meat and poultry, 
      and fish were analyzed in a survival analysis. RESULTS: Adjusting for 
      breast-feeding duration, age at first cereal introduction, ethnicity, HLA 
      genotype, family history of T1DM, and total caloric intake, higher maternal 
      intake of potatoes (hazard ratio for one standard deviation difference: 0.49, 95% 
      confidence interval: 0.28-0.86) was associated with a delayed time to IA onset. 
      No other food groups ingested during pregnancy were associated with IA in the 
      child. CONCLUSIONS: The composition of the maternal diet during pregnancy may 
      play a role in the offspring's risk of development of IA and potentially T1DM.
FAU - Lamb, Molly M
AU  - Lamb MM
AD  - Department of Preventive Medicine and Biometrics, University of Colorado at 
      Denver and Health Sciences Center, Denver, CO, USA.
FAU - Myers, Mark A
AU  - Myers MA
FAU - Barriga, Katherine
AU  - Barriga K
FAU - Zimmet, Paul Z
AU  - Zimmet PZ
FAU - Rewers, Marian
AU  - Rewers M
FAU - Norris, Jill M
AU  - Norris JM
LA  - eng
GR  - R01 DK049654/DK/NIDDK NIH HHS/United States
GR  - DK32493/DK/NIDDK NIH HHS/United States
GR  - R01-DK49654/DK/NIDDK NIH HHS/United States
GR  - P30-DK-57516/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080124
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (islet cell antibody)
SB  - IM
MH  - Age of Onset
MH  - Animals
MH  - Autoantibodies/*blood
MH  - Breast Feeding
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*epidemiology/genetics/immunology
MH  - *Diet
MH  - Edible Grain
MH  - Female
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Infant
MH  - *Infant Food
MH  - Infant, Newborn
MH  - Male
MH  - Milk
MH  - Pregnancy/*physiology
MH  - Solanum tuberosum
MH  - Vegetables
EDAT- 2008/01/29 09:00
MHDA- 2008/08/07 09:00
CRDT- 2008/01/29 09:00
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/08/07 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - PDI311 [pii]
AID - 10.1111/j.1399-5448.2007.00311.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2008 Apr;9(2):135-41. doi: 10.1111/j.1399-5448.2007.00311.x. 
      Epub 2008 Jan 24.