PMID- 18221462
OWN - NLM
STAT- MEDLINE
DCOM- 20090601
LR  - 20080516
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 19
IP  - 4
DP  - 2008 Jun
TI  - Use of Phadiatop Infant in diagnosis of specific sensitization in young children 
      with wheeze or eczema.
PG  - 337-41
LID - 10.1111/j.1399-3038.2007.00649.x [doi]
AB  - Wheezing and eczema are common symptoms in young children and it is important to 
      disclose sensitization for correct management. The objective of this study was to 
      assess the diagnostic values of Phadiatop Infant, an in vitro test for graded 
      determination of immunoglobulin E (IgE) antibodies to food and inhalant 
      allergens. One-hundred and forty-nine children (median age 1.4 yr) with symptoms 
      of wheezing (51%) eczema (28%) or a combination of both (21%) were classified as 
      atopic or non-atopic based on case history, atopic history, physical examination 
      and determination of IgE antibodies. The clinical performance of Phadiatop Infant 
      was evaluated for 145 children against this classification in a blinded manner to 
      the allergist. Fifty-one children were classified as atopic of which Phadiatop 
      Infant identified 49. Ninety-four were non-atopic of which the test identified 
      90. This resulted in a sensitivity of 96%, a specificity of 96%, a positive and a 
      negative predictive value of 94% and 98%, respectively. Logistic regression 
      showed that probability had to be assessed as atopic increased with increasing 
      Phadiatop Infant values. These results suggest that Phadiatop Infant can be 
      recommended as an adjunct to the clinical information in the differential 
      diagnosis on IgE-mediated allergy in young children. The test thus provides an 
      opportunity for early correct diagnosis and identification of subjects at risk 
      for whom intervention may be necessary.
FAU - Lau, Susanne
AU  - Lau S
AD  - Charite Medical University, Department of Pediatric Pneumology and Immunology, 
      Berlin, Germany. susanne.lau@charite.de
FAU - Nilsson, Monika
AU  - Nilsson M
FAU - Sulser, Claudia
AU  - Sulser C
FAU - Schulz, Gabriele
AU  - Schulz G
FAU - Borres, Magnus P
AU  - Borres MP
FAU - Wahn, Ulrich
AU  - Wahn U
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080124
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child, Preschool
MH  - Eczema/blood/*diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/*blood/immunology
MH  - Infant
MH  - Male
MH  - Predictive Value of Tests
MH  - Respiratory Sounds/*diagnosis/immunology
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Sweden
EDAT- 2008/01/29 09:00
MHDA- 2009/06/02 09:00
CRDT- 2008/01/29 09:00
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2009/06/02 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - PAI649 [pii]
AID - 10.1111/j.1399-3038.2007.00649.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2008 Jun;19(4):337-41. doi: 
      10.1111/j.1399-3038.2007.00649.x. Epub 2008 Jan 24.