PMID- 18221467
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20081010
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 19
IP  - 6
DP  - 2008 Sep
TI  - Relationship between adipokines and manifestations of childhood asthma.
PG  - 535-40
LID - 10.1111/j.1399-3038.2007.00690.x [doi]
AB  - Although the prevalences of asthma and obesity are increasing substantially in 
      recent decades, very little is known about the possible association between them. 
      We evaluated the roles of leptin, adiponectin, and resistin, which are adipokines 
      produced by adipose tissue, on childhood asthma, and their association with 
      pulmonary function and bronchial hyperresponsiveness. We studied 149 atopic 
      asthmatic children, 37 non-atopic asthmatic children, and 54 healthy children. 
      Body mass index was calculated using height and weight, which were measured on 
      the same day that pulmonary function tests and methacholine challenge tests were 
      performed. Skin prick tests were performed, and total eosinophil count, total 
      serum immunoglobulin E (IgE), serum eosinophil cationic protein, leptin, 
      adiponectin, and resistin were measured in all subjects. Atopic asthmatics had 
      lower resistin levels compared with non-atopic asthma and control groups, but 
      leptin and adiponectin did not show any difference among these three groups. 
      Resistin demonstrated positive correlation with methacholine PC(20) and negative 
      correlations with eosinophil count and serum total IgE. Leptin and adiponectin 
      showed associations with forced expiratory volume in 1 s or forced expiratory 
      flow between 25-75%. Multiple regression analysis revealed that resistin was a 
      significant predictive factor for asthma. There was no direct association between 
      asthma and leptin or adiponectin. Our findings suggest that resistin may play a 
      negative predictive role in asthma. Adiponectin and leptin showed close 
      associations with pulmonary function and may have disease-modifying effects in 
      children with asthma.
FAU - Kim, Kyung W
AU  - Kim KW
AD  - Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for 
      Medical Sciences, Research Center for Human Natural Defense System, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Shin, Youn H
AU  - Shin YH
FAU - Lee, Kyung E
AU  - Lee KE
FAU - Kim, Eun S
AU  - Kim ES
FAU - Sohn, Myung H
AU  - Sohn MH
FAU - Kim, Kyu-Earn
AU  - Kim KE
LA  - eng
PT  - Journal Article
DEP - 20080125
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Asthma/blood/immunology/*physiopathology
MH  - Body Mass Index
MH  - Child
MH  - Eosinophil Cationic Protein/blood
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leptin/*blood
MH  - Male
MH  - Resistin/*blood
MH  - Skin Tests
EDAT- 2008/01/29 09:00
MHDA- 2009/05/15 09:00
CRDT- 2008/01/29 09:00
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - PAI690 [pii]
AID - 10.1111/j.1399-3038.2007.00690.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2008 Sep;19(6):535-40. doi: 
      10.1111/j.1399-3038.2007.00690.x. Epub 2008 Jan 25.