PMID- 18221800
OWN - NLM
STAT- MEDLINE
DCOM- 20090519
LR  - 20131121
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 48
IP  - 2
DP  - 2009 Mar-Apr
TI  - Homocysteine (Hcy) and cognitive performance in a population sample of elderly 
      Brazilians.
PG  - 142-5
LID - 10.1016/j.archger.2007.12.002 [doi]
AB  - Hyperhomocysteinemia (HHcy) has been suggested as a predictive factor of 
      cognitive alterations. Brazil has one of the highest aging dementia rates among 
      the world's emerging countries. The objective of this study was to assess the 
      influence of Hcy levels on the cognitive performance of low-income elderly. This 
      cross-sectional study was developed in an urban center in the Northeast of Brazil 
      and included 205 eligible community-dwelling older adults. A multidimensional 
      questionnaire was used to evaluate sociodemographic aspects, health status and 
      overall clinical aspects. Cognitive performance was assessed by the Portuguese 
      version of Mini Mental State Examination (MMSE). Folic acid, vitamin B(12) and 
      Hcy levels were determined by chemical luminescence. The association between 
      sociodemographic variables, Hcy, serum vitamin B(12), folic acid levels and total 
      MMSE score was assessed by multiple linear regression. Values indicative of HHcy 
      (>12micromol/l) were found in 34.8% of the individuals. Age, schooling and HHcy 
      showed a negative correlation with the MMSE score. The R(2) values of isolated 
      HHcy explain only 4% of the MMSE score variance, however when associated to 
      schooling and age, this model explained up to 25% of this association.
FAU - Tassino, Marcio
AU  - Tassino M
AD  - Universidade Federal do Rio Grande do Norte, Petropolis, Natal, Brazil.
FAU - Campos, Tania Fernandes
AU  - Campos TF
FAU - Guerra, Ricardo Oliveira
AU  - Guerra RO
LA  - eng
PT  - Journal Article
DEP - 20080124
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Brazil/epidemiology
MH  - Brief Psychiatric Rating Scale
MH  - Cross-Sectional Studies
MH  - Dementia/*blood/epidemiology
MH  - Educational Status
MH  - Female
MH  - Folic Acid/blood
MH  - Health Status Indicators
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Poverty Areas
MH  - Prevalence
MH  - Urban Population
MH  - Vitamin B 12/blood
EDAT- 2008/01/29 09:00
MHDA- 2009/05/20 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/06/19 00:00 [received]
PHST- 2007/11/29 00:00 [revised]
PHST- 2007/12/04 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2009/05/20 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S0167-4943(07)00243-9 [pii]
AID - 10.1016/j.archger.2007.12.002 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2009 Mar-Apr;48(2):142-5. doi: 
      10.1016/j.archger.2007.12.002. Epub 2008 Jan 24.