PMID- 18221843
OWN - NLM
STAT- MEDLINE
DCOM- 20081104
LR  - 20171116
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 129
IP  - 3-4
DP  - 2008 Jun 22
TI  - Phenotypic and functional modulation of bone marrow-derived dendritic cells by 
      porcine reproductive and respiratory syndrome virus.
PG  - 281-93
LID - 10.1016/j.vetmic.2007.12.002 [doi]
AB  - It is well documented that there is a delay in the development of effective 
      immunity to porcine reproductive and respiratory syndrome virus (PRRSV) in 
      infected and vaccinated pigs. This suggests that PRRSV might possess some 
      inherent properties to evade host defense mechanisms during the early stage of 
      infection. Dendritic cells (DCs) play a crucial role in the activation and 
      control of T-cells in response to viral antigens. In this study, we investigated 
      the phenotypic and functional property changes of bone marrow-derived immature 
      DCs (BM-imDCs) that take place after infection by PRRSV. Results showed that 
      BM-imDCs were permissive to PRRSV infection, as productive replication took place 
      in these cells. A down-regulated expression of MHC I molecules along with an 
      up-regulated expression of CD80/86 is observed at 48 h following infection. Also 
      at 48h following PRRSV infection, a significant increase of IL-10 secretion by 
      BM-imDCs was noticed. Results suggest that the inhibited expression of MHC I and 
      the enhanced secretion of IL-10 by BM-imDCs after PRRSV infection might be among 
      the strategies used by the virus to evade the host immune defenses.
FAU - Chang, Hsueh-Chen
AU  - Chang HC
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung, Taiwan, ROC.
FAU - Peng, Yu-Tang
AU  - Peng YT
FAU - Chang, Hsiu-Luan
AU  - Chang HL
FAU - Chaung, Hso-Chi
AU  - Chaung HC
FAU - Chung, Wen-Bin
AU  - Chung WB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071214
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - B7-1 Antigen/immunology
MH  - B7-2 Antigen/immunology
MH  - Bone Marrow Cells
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/virology
MH  - Flow Cytometry/veterinary
MH  - *Gene Expression Regulation, Viral
MH  - *Genes, MHC Class I
MH  - Immunophenotyping
MH  - Interleukin-10/biosynthesis/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/immunology/*pathogenicity
MH  - Swine
EDAT- 2008/01/29 09:00
MHDA- 2008/11/05 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/10/09 00:00 [received]
PHST- 2007/11/30 00:00 [revised]
PHST- 2007/12/05 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/11/05 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S0378-1135(07)00617-7 [pii]
AID - 10.1016/j.vetmic.2007.12.002 [doi]
PST - ppublish
SO  - Vet Microbiol. 2008 Jun 22;129(3-4):281-93. doi: 10.1016/j.vetmic.2007.12.002. 
      Epub 2007 Dec 14.