PMID- 18221890
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20170916
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 40
IP  - 2
DP  - 2008 Apr 1
TI  - Investigation into the neural correlates of emotional augmentation of clinical 
      pain.
PG  - 759-766
LID - S1053-8119(07)01110-X [pii]
LID - 10.1016/j.neuroimage.2007.12.016 [doi]
AB  - Although depressive mood is an important psychological determinate of chronic 
      pain, the neural circuitry that mediates its influence on the pain experience is 
      largely unknown. We used functional magnetic resonance imaging (FMRI) to 
      investigate the neurophysiological interactions between depressive symptoms and 
      disease-relevant pain in rheumatoid arthritis (RA) patients. RA is associated 
      with chronic joint pain and swelling, but peripheral joint pathology often does 
      not fully explain the amount of pain a patient experiences. We investigated the 
      neural circuitry that relates joint pain and depressive symptoms and contrasted 
      this with experimental heat pain. We hypothesized that (1) depressive symptoms 
      influence the cerebral processing of provoked joint pain in RA, and (2) the 
      interaction of depressive symptoms with pain processing contributes to the pain 
      RA patients experience on a daily basis. Twenty patients underwent whole brain 
      FMRI during which disease-relevant joint pain was provoked. Depressive symptoms 
      were assessed using the Beck Depression Inventory (BDI). The tender-to-swollen 
      joint ratio (T/S) was assessed as one component of the patients' clinical pain. 
      BDI scores correlated significantly with T/S and medial prefrontal cortex (MPFC) 
      activation during provoked joint pain. The association between BDI scores and T/S 
      was partly mediated by the MPFC activation. Furthermore, the MPFC activation 
      co-varied significantly with the FMRI signal in limbic areas and in areas that 
      process self-relevant information. These results suggest that the MPFC may play 
      an important role in mediating the relationship between depressive symptoms and 
      clinical pain severity in RA, possibly by engaging brain areas important for 
      affective and self-relevant processing.
FAU - Schweinhardt, Petra
AU  - Schweinhardt P
AD  - Centre for Functional Magnetic Resonance Imaging, Department of Clinical 
      Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK; Department of 
      Physiology, Anatomy and Genetics, Oxford University, South Parks Road, Oxford, 
      OX1 3QX, UK. Electronic address: petra.schweinhardt@mcgill.ca.
FAU - Kalk, Nicola
AU  - Kalk N
AD  - Centre for Functional Magnetic Resonance Imaging, Department of Clinical 
      Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
FAU - Wartolowska, Karolina
AU  - Wartolowska K
AD  - Centre for Functional Magnetic Resonance Imaging, Department of Clinical 
      Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK; Department of 
      Physiology, Anatomy and Genetics, Oxford University, South Parks Road, Oxford, 
      OX1 3QX, UK.
FAU - Chessell, Iain
AU  - Chessell I
AD  - N & GI CEDD, Glaxo Smith Kline, Harlow, CM19 5AD, UK.
FAU - Wordsworth, Paul
AU  - Wordsworth P
AD  - Department of Rheumatology, Nuffield Orthopedic Centre, Oxford, OX3 7LD, UK.
FAU - Tracey, Irene
AU  - Tracey I
AD  - Centre for Functional Magnetic Resonance Imaging, Department of Clinical 
      Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK; Department of 
      Physiology, Anatomy and Genetics, Oxford University, South Parks Road, Oxford, 
      OX1 3QX, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071223
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
EIN - Neuroimage. 2011 May 1;56(1):384
MH  - Arthritis, Rheumatoid/*physiopathology
MH  - Brain/*physiopathology
MH  - Depression/*physiopathology
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Pain/*physiopathology/*psychology
EDAT- 2008/01/29 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/04/09 00:00 [received]
PHST- 2007/11/29 00:00 [revised]
PHST- 2007/12/05 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S1053-8119(07)01110-X [pii]
AID - 10.1016/j.neuroimage.2007.12.016 [doi]
PST - ppublish
SO  - Neuroimage. 2008 Apr 1;40(2):759-766. doi: 10.1016/j.neuroimage.2007.12.016. Epub 
      2007 Dec 23.