PMID- 18222411
OWN - NLM
STAT- MEDLINE
DCOM- 20080317
LR  - 20151119
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 195
IP  - 3
DP  - 2008 Mar
TI  - Does homocysteine contribute to bone disease in hyperparathyroidism?
PG  - 374-7; discussion 377-8
LID - 10.1016/j.amjsurg.2007.12.011 [doi]
AB  - BACKGROUND: Osteoporosis is a complication of hyperparathyroidism (HPT). 
      Hyperhomocysteinemia (HHCy) is an independent risk factor for osteoporotic 
      fractures. We hypothesize that HHCy correlates with bone disease in HPT. METHODS: 
      A prospectively collected database of 250 patients treated for HPT was reviewed. 
      Patients were categorized into 3 groups: group I, normal renal function; group 2, 
      mild renal insufficiency; and group 3, secondary HPT with end-stage renal disease 
      on dialysis. Serum homocysteine levels, markers of bone metabolism, and bone 
      density studies were examined. RESULTS: The prevalence of HHCy in group 1 (208 
      patients) was 5%, in group 2 (23 patients), 82%, and in group 3 (19 patients), 
      78%. Mean (+/-SD) preoperative homocysteinemia (HCy) levels in groups 1, 2, and 3 
      were 9.3 +/- 4.0, 20 +/- 10.2, and 20.6 +/- 12.3 micromol/L, respectively. 
      Elevated serum markers of bone metabolism increased significantly with decreasing 
      renal function. CONCLUSIONS: Prevalence of HHCy is low in HPT patients with 
      normal renal function. It is significantly greater in those with 
      dialysis-independent and -dependent renal insufficiency. HHCy correlates with 
      other serum markers of bone metabolism in HPT and may be useful for monitoring 
      progression or improvement.
FAU - Alley, Robin A
AU  - Alley RA
AD  - Department of General Surgery, Rush University Medical Center, 1653 W. Congress 
      Pkwy., Chicago, IL 60612, USA.
FAU - Chen, Emery L
AU  - Chen EL
FAU - Beyer, Todd D
AU  - Beyer TD
FAU - Prinz, Richard A
AU  - Prinz RA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Biomarkers/blood
MH  - Bone Density
MH  - Bone and Bones/*metabolism
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Hyperparathyroidism/*complications/surgery
MH  - Kidney Diseases/blood/etiology
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/blood/*etiology
MH  - Parathyroidectomy
MH  - Prospective Studies
EDAT- 2008/01/29 09:00
MHDA- 2008/03/18 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/12/04 00:00 [received]
PHST- 2007/12/04 00:00 [revised]
PHST- 2007/12/04 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/03/18 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S0002-9610(07)00980-4 [pii]
AID - 10.1016/j.amjsurg.2007.12.011 [doi]
PST - ppublish
SO  - Am J Surg. 2008 Mar;195(3):374-7; discussion 377-8. doi: 
      10.1016/j.amjsurg.2007.12.011.