PMID- 18222435
OWN - NLM
STAT- MEDLINE
DCOM- 20081210
LR  - 20081110
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 90
IP  - 5
DP  - 2008 Nov
TI  - Follicular-fluid neurotrophin levels in women undergoing assisted reproductive 
      technology for different etiologies of infertility.
PG  - 1611-5
LID - 10.1016/j.fertnstert.2007.08.085 [doi]
AB  - OBJECTIVE: To determine follicular-fluid neurotrophin levels in women undergoing 
      assisted reproductive techniques for different etiologies of infertility. DESIGN: 
      Prospective observational study. SETTING: Academically affiliated assisted 
      reproductive techniques unit. PATIENT(S): One hundred six patients undergoing an 
      IVF cycle for different etiologies of infertility. INTERVENTION(S): Assessment of 
      follicular fluid for neurotrophins. MAIN OUTCOME MEASURE(S): Follicular-fluid 
      neurotrophin concentrations. RESULT(S): Women with a history of endometriosis 
      have significantly lower follicular-fluid brain-derived neurotrophic factor 
      (BDNF) levels compared with women with male-factor (control) infertility. Women 
      with diminished ovarian reserve have significantly higher levels of nerve growth 
      factor (NGF) compared with women with male-factor infertility. Follicular-fluid 
      BDNF levels tend to be lower in patients with endometriosis and diminished 
      ovarian reserve and to be higher in patients with polycystic ovarian syndrome. 
      Interestingly, NGF concentrations follow the opposite trend. Finally, 
      follicular-fluid NT-3 concentrations are similar in women with different 
      etiologies of infertility. CONCLUSION(S): Endometriosis is associated with low 
      follicular-fluid BDNF levels, and diminished ovarian reserve is associated with 
      increased follicular-fluid NGF levels.
FAU - Buyuk, Erkan
AU  - Buyuk E
AD  - Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New 
      York, USA.
FAU - Seifer, David B
AU  - Seifer DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080128
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Case-Control Studies
MH  - Endometriosis/complications/metabolism
MH  - Female
MH  - *Fertilization in Vitro
MH  - Follicular Fluid/*chemistry
MH  - Humans
MH  - Infertility/etiology/metabolism/*therapy
MH  - Nerve Growth Factor/analysis
MH  - Nerve Growth Factors/*analysis
MH  - Polycystic Ovary Syndrome/complications/metabolism
MH  - Pregnancy
MH  - Prospective Studies
EDAT- 2008/01/29 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/06/12 00:00 [received]
PHST- 2007/08/16 00:00 [revised]
PHST- 2007/08/16 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S0015-0282(07)03740-5 [pii]
AID - 10.1016/j.fertnstert.2007.08.085 [doi]
PST - ppublish
SO  - Fertil Steril. 2008 Nov;90(5):1611-5. doi: 10.1016/j.fertnstert.2007.08.085. Epub 
      2008 Jan 28.