PMID- 18222478
OWN - NLM
STAT- MEDLINE
DCOM- 20081124
LR  - 20211020
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Print)
IS  - 0022-4804 (Linking)
VI  - 150
IP  - 1
DP  - 2008 Nov
TI  - Females exhibit relative resistance to depressive effects of tumor necrosis 
      factor-alpha on the myocardium.
PG  - 92-9
LID - 10.1016/j.jss.2007.12.777 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) plays a critical role in 
      myocardial dysfunction following acute injury. It is unknown, however, if a 
      gender-specific response to TNF infusion exists in isolated rat hearts. 
      Elucidating such mechanisms is important to understanding the myocardial gender 
      differences during acute injury. We hypothesize that females will exhibit a 
      relative resistance to TNF-induced myocardial dysfunction compared to males and 
      that menstrual cycle would influence the degree of female myocardial resistance 
      to TNF-induced myocardial functional depression. MATERIALS AND METHODS: Adult 
      male, proestrus female, and metestrus/diestrus female hearts were subjected to 60 
      min of TNF infusion at 10,000 pg/mL.min via Langendorff. Myocardial contractile 
      function (left ventricular developed pressure, and the positive/negative first 
      derivative of pressure) was continuously recorded. RESULTS: 10,000 pg/mL.min of 
      TNF markedly depressed myocardial function in males compared with other doses of 
      TNF. Myocardial function was significantly decreased in males compared to females 
      following TNF infusion. Additionally, both the proestrus and the 
      metestrus/diestrus females exhibited equal resistance to TNF-induced myocardial 
      dysfunction. CONCLUSION: Our study shows that females exhibit a significantly 
      greater degree of resistance to TNF-induced myocardial depression. Moreover, data 
      from this study suggest that fluctuations in estrogen during the reproductive 
      cycle may have little to no influence on TNF-induced myocardial depression.
FAU - Sando, Ian C
AU  - Sando IC
AD  - Department of Surgery, Indiana University School of Medicine, Indianapolis, 
      Indiana, USA.
FAU - Wang, Yue
AU  - Wang Y
FAU - Crisostomo, Paul R
AU  - Crisostomo PR
FAU - Markel, Troy A
AU  - Markel TA
FAU - Sharma, Rahul
AU  - Sharma R
FAU - Erwin, Graham S
AU  - Erwin GS
FAU - Guzman, Mike J
AU  - Guzman MJ
FAU - Meldrum, Daniel R
AU  - Meldrum DR
FAU - Wang, Meijing
AU  - Wang M
LA  - eng
GR  - K99 HL087607/HL/NHLBI NIH HHS/United States
GR  - R01 GM070628-04/GM/NIGMS NIH HHS/United States
GR  - R01 GM070628/GM/NIGMS NIH HHS/United States
GR  - K99/R00 HL0876077/HL/NHLBI NIH HHS/United States
GR  - F32 HL085982/HL/NHLBI NIH HHS/United States
GR  - F32HL085982/HL/NHLBI NIH HHS/United States
GR  - K99 HL087607-01/HL/NHLBI NIH HHS/United States
GR  - R01 HL085595/HL/NHLBI NIH HHS/United States
GR  - R01HL085595/HL/NHLBI NIH HHS/United States
GR  - K99 HL087607-02/HL/NHLBI NIH HHS/United States
GR  - R01GM070628/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080117
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - *Estrous Cycle
MH  - Female
MH  - In Vitro Techniques
MH  - Male
MH  - Myocardial Contraction/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Sex Characteristics
MH  - Tumor Necrosis Factor-alpha/*pharmacology
PMC - PMC2586947
MID - NIHMS74914
EDAT- 2008/01/29 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/11/01
CRDT- 2008/01/29 09:00
PHST- 2007/08/17 00:00 [received]
PHST- 2007/10/25 00:00 [revised]
PHST- 2007/12/06 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - S0022-4804(07)02400-6 [pii]
AID - 10.1016/j.jss.2007.12.777 [doi]
PST - ppublish
SO  - J Surg Res. 2008 Nov;150(1):92-9. doi: 10.1016/j.jss.2007.12.777. Epub 2008 Jan 
      17.