PMID- 18222703
OWN - NLM
STAT- MEDLINE
DCOM- 20080410
LR  - 20220318
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 37
IP  - 3
DP  - 2008 Mar
TI  - Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 
      interact directly with the fibroblast growth factor (FGF) receptor.
PG  - 528-36
LID - 10.1016/j.mcn.2007.12.001 [doi]
AB  - The neuronal cell adhesion molecule (CAM) L1 promotes axonal outgrowth, 
      presumably through an interaction with the fibroblast growth factor receptor 
      (FGFR). The present study demonstrates a direct interaction between L1 
      fibronectin type III (FN3) modules I-V and FGFR1 immunoglobulin (Ig) modules II 
      and III by surface plasmon resonance analysis. Binding of L1 to FGFR1 was 
      enhanced by adenosine 5'-triphosphate (ATP), adenylylmethylenediphosphonate 
      (AMP-PCP), and guanosine-5'-triphosphate (GTP), but not adenosine monophosphate 
      (AMP). The L1-FN3 modules were capable of activating FGFR1, reflected by receptor 
      phosphorylation, and this resulted in the induction of differentiation of primary 
      neurons, reflected by neurite outgrowth. Furthermore, ATP modulated L1-induced 
      neuronal differentiation and FGFR1 phosphorylation through regulation of the 
      L1-FGFR1 interaction.
FAU - Kulahin, Nikolaj
AU  - Kulahin N
AD  - Protein Laboratory, Department of Neuroscience and Pharmacology, University of 
      Copenhagen, Copenhagen, Denmark. kulahin@plab.ku.dk
FAU - Li, Shizhong
AU  - Li S
FAU - Hinsby, Anders
AU  - Hinsby A
FAU - Kiselyov, Vladislav
AU  - Kiselyov V
FAU - Berezin, Vladimir
AU  - Berezin V
FAU - Bock, Elisabeth
AU  - Bock E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071214
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Fibronectins)
RN  - 0 (Neural Cell Adhesion Molecule L1)
RN  - 25612-73-1 (Adenylyl Imidodiphosphate)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/metabolism/pharmacology
MH  - Adenylyl Imidodiphosphate/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Cells, Cultured
MH  - Cerebellum/cytology
MH  - Fibroblast Growth Factors/*pharmacology
MH  - Fibronectins/*metabolism
MH  - Guanosine Triphosphate/pharmacology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Cell Adhesion Molecule L1/*metabolism
MH  - Neurites/drug effects
MH  - Neurons/cytology/*drug effects/*metabolism
MH  - Phosphorylation/drug effects
MH  - Rats
EDAT- 2008/01/29 09:00
MHDA- 2008/04/11 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/05/16 00:00 [received]
PHST- 2007/11/30 00:00 [revised]
PHST- 2007/12/04 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/04/11 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S1044-7431(07)00278-3 [pii]
AID - 10.1016/j.mcn.2007.12.001 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2008 Mar;37(3):528-36. doi: 10.1016/j.mcn.2007.12.001. Epub 
      2007 Dec 14.