PMID- 18222974
OWN - NLM
STAT- MEDLINE
DCOM- 20080314
LR  - 20181201
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 233
IP  - 2
DP  - 2008 Feb
TI  - Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model.
PG  - 192-9
LID - 10.3181/0708-RM-222 [doi]
AB  - In this study, we investigated the effect of the methanol extract of fruits of 
      Vitis amurensis Rupr. (Vitaceae; MEVA) on the mast cell-mediated allergy model 
      and studied the possible mechanism of action. Mast cell-mediated allergic disease 
      is involved in many diseases, such as asthma and sinusitis. The discovery of 
      drugs for the treatment of allergic disease is an important subject in human 
      health. MEVA inhibited compound 48/80-induced systemic reactions and serum 
      histamine release in a dose-dependent manner in mice. MEVA decreased 
      immunoglobulin E (IgE)-mediated local allergic reactions, passive cutaneous 
      anaphylaxis. MEVA dose-dependently reduced histamine release from mast cells 
      activated by compound 48/80 or IgE. The inhibitory effect of MEVA on histamine 
      release was mediated by the modulation of intracellular calcium. In addition, 
      MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 
      (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 
      (IL-6), and IL-8 in human mast cells. The inhibitory effect of MEVA on these 
      proinflammatory cytokines was p38 mitogen-activated protein kinase and nuclear 
      factor-kappaB (NF-kappaB) dependent. Our findings provide evidence that MEVA 
      inhibits mast cell-derived, immediate-type allergic reactions and involvement of 
      proinflammatory cytokines, p38 MAPK, and NF-kappaB in these effects.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Department of Pharmacology, School of Medicine, Kyungpook National University, 
      Daegu 700-422, South Korea.
FAU - Kwon, Taeg Kyu
AU  - Kwon TK
FAU - Shin, Tae-Yong
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Calcium/metabolism
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Enzyme Activation/drug effects
MH  - Histamine Release/drug effects
MH  - Hypersensitivity/*drug therapy/immunology
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology/metabolism
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects/immunology
MH  - Plant Extracts/chemistry/pharmacology
MH  - Rats
MH  - Vitis/*chemistry
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2008/01/29 09:00
MHDA- 2008/03/15 09:00
CRDT- 2008/01/29 09:00
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/03/15 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - 233/2/192 [pii]
AID - 10.3181/0708-RM-222 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2008 Feb;233(2):192-9. doi: 10.3181/0708-RM-222.