PMID- 18225444
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20181201
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 191
IP  - 4-5
DP  - 2007 Apr-May
TI  - [White adipose tissue, inflammation and atherosclerosis].
PG  - 897-908; discussion 908-10
AB  - Our view of white adipose tissue (WAT) has changed over the last decade, from an 
      inert triglyceride storage tissue to a highly active metabolic organ. Indeed, WAT 
      secretes proinflammatory cytokines such TNF-a, interleukin-1 (IL-1), 
      interleukin-1 receptor antagonist (IL-1Ra), and interleukin-6 (IL-6), and 
      chemokines such as monocyte chemoattractant protein-1 (MCP-1), interferon gamma 
      inducible protein 10 (IP-10), interleukin-8 (IL-8), RANTES, and peptides with 
      hormone-like actions such as adiponectin, leptin and resistin. Through their 
      paracrine actions these factors contribute to local WAT inflammation, 
      neoangiogenesis and differentiation. On entering the systemic circulation they 
      can contribute to creating or maintaining a systemic inflammatory state, 
      hypertension and insulin resistance, and can also affect central control of food 
      intake. When located around organs such as the kidney, heart and blood vessels, 
      WAT can adversely affect organ function by secreting cytokines and chemokines. 
      For example, perivascular WAT which secretes proatherogenic cytokines and 
      chemokines and which is present around large and medium-sized arteries, could 
      contribute to the development of atherosclerotic lesions by attracting 
      inflammatory cells and stimulating neoangiogenesis, thereby amplifying the 
      chronic vascular inflammation which is the hallmark of atherosclerosis.
FAU - Meier, Christoph A
AU  - Meier CA
AD  - Department de Medecine Interne, Triemli Hopital, Birmensdorferstrasse 497, 
      CH-8063 Zurich, Suisse.
FAU - Thalmann, Sebastien
AU  - Thalmann S
LA  - fre
PT  - Comparative Study
PT  - Journal Article
PT  - Review
TT  - Tissu adipeux, inflammation et atherome.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
RN  - 0 (Angiogenic Proteins)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adipose Tissue, White/*metabolism
MH  - Angiogenic Proteins/metabolism
MH  - Atherosclerosis/*etiology/metabolism/physiopathology
MH  - Chemokines/metabolism/physiology
MH  - Cytokines/metabolism/physiology
MH  - Humans
MH  - Inflammation/metabolism/*physiopathology
MH  - Insulin Resistance
MH  - Obesity/*metabolism/physiopathology
RF  - 42
EDAT- 2008/01/30 09:00
MHDA- 2008/02/26 09:00
CRDT- 2008/01/30 09:00
PHST- 2008/01/30 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2008/01/30 09:00 [entrez]
PST - ppublish
SO  - Bull Acad Natl Med. 2007 Apr-May;191(4-5):897-908; discussion 908-10.