PMID- 18225577
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20081121
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 27
IP  - 6B
DP  - 2007 Nov-Dec
TI  - Association of -1171 promoter polymorphism of matrix metalloproteinase-3 with 
      increased risk for oral cancer.
PG  - 4095-100
AB  - BACKGROUND: Matrix metalloproteinase-3 (MMP-3) plays a pivotal role in 
      inflammation and thrombosis. Increased levels of MMP-3 have been correlated with 
      progression of oncogenesis and metastasis. Inflammation-related factors have 
      recently been found to contribute to the development of malignancies. The present 
      study investigated the possible association of -1171 5A/6A polymorphism, which 
      influences expression of MMP-3, with risk for oral cancer. MATERIALS AND METHODS: 
      This polymorphism was examined by restriction enzyme analysis in 160 patients 
      with oral squamous cell carcinoma (OSCC) and 156 healthy controls of equivalent 
      gender, age and ethnicity (Greeks and Germans). RESULTS: A significant increase 
      of 5A/6A heterozygotes was observed in the whole group and several subgroups of 
      patients compared to controls (p < 0.05). Nevertheless, in these subgroups and 
      the whole patient group, the 5A allele and carrier frequencies did not differ 
      significantly from those of the control group. The only significant increase of 
      5A allele-related frequencies (p < 0.05) in comparison with controls was observed 
      in subgroups of patients with a positive family history of cancer (5A allele 
      carrier frequency only), with advanced stages of cancer (5A allele frequency 
      only) and without positive history of thrombophilia (both 5A allele and carrier 
      frequencies). In addition, the genotypes containing the 5A allele (5A/5A and 
      5A/6A) had a double risk of OSSC development in smokers (odds ratio (OR) 2.16, 
      95% confidence interval (CI) 1.04-4.48 and OR 1.78, 95% CI 1.01-3.13, 
      respectively). CONCLUSION: The results of this study suggest that the high 
      expression 5A allele of the MMP-3 gene is associated with an increased risk for 
      oral cancer in certain individuals.
FAU - Vairaktaris, Eleftherios
AU  - Vairaktaris E
AD  - Department of Oral and Maxillofacial Surgery, University of Athens Medical 
      School, Vas. Sofias 93 and Dim. Soutsou 1, Athens 11521, Greece. 
      lvairakt@med.uoa.gr
FAU - Yapijakis, Christos
AU  - Yapijakis C
FAU - Vasiliou, Stavros
AU  - Vasiliou S
FAU - Derka, Spyridoula
AU  - Derka S
FAU - Nkenke, Emeka
AU  - Nkenke E
FAU - Serefoglou, Zoe
AU  - Serefoglou Z
FAU - Vorris, Eleni
AU  - Vorris E
FAU - Vylliotis, Antonis
AU  - Vylliotis A
FAU - Ragos, Vasilios
AU  - Ragos V
FAU - Neukam, Friedrich W
AU  - Neukam FW
FAU - Patsouris, Efstratios
AU  - Patsouris E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*enzymology/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Mouth Neoplasms/*enzymology/*genetics
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
EDAT- 2008/01/30 09:00
MHDA- 2008/02/13 09:00
CRDT- 2008/01/30 09:00
PHST- 2008/01/30 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2008/01/30 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2007 Nov-Dec;27(6B):4095-100.