PMID- 18225589
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20161124
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 27
IP  - 6B
DP  - 2007 Nov-Dec
TI  - Antitumor effect of acridine orange under ultrasonic irradiation in vitro.
PG  - 4179-84
AB  - BACKGROUND: Sonodynamic synergistic antitumor therapy is a promising new 
      methodology for cancer treatment. MATERIALS AND METHODS: To determine the 
      antitumor effects of ultrasound (US) in the presence of acridine orange (AO), 1.0 
      microg/ml solution of AO was tested as a sonodynamic compound against sarcoma 180 
      cells in vitro. RESULTS: After US irradiation at 2.0 W/cm2 for 60 sec, the 
      survival rate of tumor cells in the presence of AO was significantly lower than 
      in its absence (p < 0.001). In the AO-treated group, the tumor cells were mostly 
      fragmented. When D-mannitol or L-histidine was used along with the AO, the 
      survival rate of tumor cells after irradiation was significantly higher than that 
      when AO alone was applied. CONCLUSION: AO could exhibit useful antitumor activity 
      under US irradiation, and the generation of singlet oxygen and hydroxyl radicals 
      is involved in the processes of tumor cell damage.
FAU - Suzuki, Norio
AU  - Suzuki N
AD  - Division of Orthopedic Surgery, Department of Neuro and Locomotor Science, Akita 
      University School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan.
FAU - Okada, Kyoji
AU  - Okada K
FAU - Chida, Shuichi
AU  - Chida S
FAU - Komori, Chiyo
AU  - Komori C
FAU - Shimada, Yoichi
AU  - Shimada Y
FAU - Suzuki, Toshio
AU  - Suzuki T
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Reactive Oxygen Species)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*pharmacology
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Free Radical Scavengers/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Reactive Oxygen Species/metabolism
MH  - Sarcoma 180/diagnostic imaging/drug therapy/metabolism/*therapy
MH  - Ultrasonic Therapy/*methods
MH  - Ultrasonography
EDAT- 2008/01/30 09:00
MHDA- 2008/02/13 09:00
CRDT- 2008/01/30 09:00
PHST- 2008/01/30 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2008/01/30 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2007 Nov-Dec;27(6B):4179-84.