PMID- 18227354
OWN - NLM
STAT- MEDLINE
DCOM- 20080611
LR  - 20121115
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 10
IP  - 3
DP  - 2008 Mar
TI  - Chronic cardiac resynchronization therapy reverses cardiac remodelling and 
      improves invasive haemodynamics of patients with severe heart failure on optimal 
      medical treatment.
PG  - 379-83
LID - 10.1093/europace/eum297 [doi]
AB  - AIMS: The aim of this study was to assess chronic invasive haemodynamic effects 
      of cardiac resynchronization therapy (CRT) in patients with severe heart failure. 
      METHODS AND RESULTS: Seventeen patients with New York Heart Association (NYHA) 
      class III or IV and QRS duration >120 ms on optimal treatments underwent CRT. 
      Haemodynamic data were obtained by cardiac catheterization before and 1 month 
      after CRT. Clinical parameters and exercise tolerance were also evaluated. 
      Chronic CRT improved haemodynamics significantly; mean pulmonary capillary wedge 
      pressure decreased from 15.9 +/- 6.1 to 10.2 +/- 5.3 mmHg (P < 0.05), systolic 
      pulmonary artery pressure decreased from 36.5 +/- 13.2 to 26.7 +/- 11.9 mmHg (P < 
      0.05), left ventricular end-diastolic pressure decreased from 15.6 +/- 7.2 to 
      10.5 +/- 7.3 mmHg (P < 0.05), end-diastolic volume decreased from 358.8 +/- 84.6 
      to 322.9 +/- 99.0 mL (P < 0.05), end-systolic volume decreased from 264.1 +/- 
      67.6 to 219.2 +/- 74.3 mL (P < 0.05), left ventricular ejection fraction 
      increased from 25.4 +/- 6.2 to 33.1 +/- 4.9% (P < 0.05), and cardiac index 
      increased from 1.9 +/- 0.4 to 2.2 +/- 0.5 L/min/m(2) (P < 0.05). Chronic CRT 
      significantly improved functional capacity such as NYHA classification, 6 min 
      walk distance, and peak oxygen uptake. CONCLUSION: Chronic CRT improved not only 
      symptoms and exercise tolerance but also invasive haemodynamics associated with 
      reversed cardiac remodelling.
FAU - Inage, Tomohito
AU  - Inage T
AD  - Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
FAU - Yoshida, Teruhisa
AU  - Yoshida T
FAU - Hiraki, Tatsuro
AU  - Hiraki T
FAU - Ohe, Masatsugu
AU  - Ohe M
FAU - Takeuchi, Tomohiro
AU  - Takeuchi T
FAU - Nagamoto, Yasutsugu
AU  - Nagamoto Y
FAU - Fukuda, Yujiro
AU  - Fukuda Y
FAU - Gondo, Takeki
AU  - Gondo T
FAU - Imaizumi, Tsutomu
AU  - Imaizumi T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20080128
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/*physiology
MH  - Cardiac Catheterization/*methods
MH  - Cardiac Pacing, Artificial/*methods
MH  - Electrocardiography
MH  - Exercise Tolerance/physiology
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Stroke Volume/*physiology
MH  - Treatment Outcome
MH  - Ventricular Remodeling/*physiology
EDAT- 2008/01/30 09:00
MHDA- 2008/06/12 09:00
CRDT- 2008/01/30 09:00
PHST- 2008/01/30 09:00 [pubmed]
PHST- 2008/06/12 09:00 [medline]
PHST- 2008/01/30 09:00 [entrez]
AID - eum297 [pii]
AID - 10.1093/europace/eum297 [doi]
PST - ppublish
SO  - Europace. 2008 Mar;10(3):379-83. doi: 10.1093/europace/eum297. Epub 2008 Jan 28.