PMID- 18227804
OWN - NLM
STAT- MEDLINE
DCOM- 20080220
LR  - 20101118
IS  - 1745-8331 (Electronic)
IS  - 1745-8323 (Linking)
VI  - 4
IP  - 2
DP  - 2008 Feb
TI  - A case of acute renal failure associated with diffuse infiltrative lymphocytosis 
      syndrome.
PG  - 110-4
LID - 10.1038/ncpneph0674 [doi]
AB  - BACKGROUND: A 58-year-old African American man with an uncontrolled HIV infection 
      presented to hospital with nephrotic syndrome and diffuse lymphadenopathy. The 
      patient had been taking highly active antiretroviral therapy (HAART; lamivudine, 
      abacavir, fosamprenavir and ritonavir) for 10 years. A renal biopsy showed acute 
      granulomatous interstitial nephritis. Despite a negative tuberculin skin test, he 
      was treated with antituberculosis drugs for 12 months without improvement of his 
      renal profile. Two months after antituberculosis treatment was discontinued, the 
      patient was readmitted to hospital because of acute renal failure. Corticosteroid 
      therapy (prednisone) was started and resulted in a marked improvement in renal 
      function. However, 18 months after steroids were discontinued, renal function 
      declined dramatically. Furthermore, the patient had CD8+ lymphocytosis as well as 
      interstitial tissue infiltration by CD8+ T lymphocytes. INVESTIGATIONS: Physical 
      examination, plasma HIV viral load, lymphocyte counts, urinalysis, tuberculin 
      skin test, liver function tests, renal ultrasonography, human leukocyte antigen 
      (HLA) typing, renal and minor salivary gland biopsies, ophthalmological 
      examination, chest radiography and culture of bronchoalveolar lavage fluid. 
      DIAGNOSIS: Acute granulomatous interstitial nephritis secondary to diffuse 
      infiltrative lymphocytosis syndrome. MANAGEMENT: HAART and prednisone.
FAU - Izzedine, Hassane
AU  - Izzedine H
AD  - Department of Nephrology, La Pitie-Salpetriere Hospital, 47-80 Boulevard de 
      l'Hopital, Assistance Publique-Hopitaux de Paris, Pierre et Marie Curie 
      University, 75013 Paris, France. hassan.izzedine@psl.aphp.fr
FAU - Brocheriou, Isabelle
AU  - Brocheriou I
FAU - Valantin, Marc-Antoine
AU  - Valantin MA
FAU - Camous, Laurent
AU  - Camous L
FAU - Bourry, Edward
AU  - Bourry E
FAU - Baumelou, Alain
AU  - Baumelou A
FAU - Deray, Gilbert
AU  - Deray G
FAU - Katlama, Christine
AU  - Katlama C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Nat Clin Pract Nephrol
JT  - Nature clinical practice. Nephrology
JID - 101261800
SB  - IM
MH  - Acute Kidney Injury/complications/*diagnosis/immunology
MH  - Biopsy, Needle
MH  - Education, Medical, Continuing
MH  - Follow-Up Studies
MH  - HIV Infections/complications/*diagnosis/immunology
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney Function Tests
MH  - Lymphocyte Count
MH  - Lymphocytosis/complications/*diagnosis/immunology
MH  - Male
MH  - Middle Aged
MH  - Nephritis, Interstitial/complications/*diagnosis/immunology
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Syndrome
EDAT- 2008/01/30 09:00
MHDA- 2008/02/21 09:00
CRDT- 2008/01/30 09:00
PHST- 2007/05/01 00:00 [received]
PHST- 2007/09/11 00:00 [accepted]
PHST- 2008/01/30 09:00 [pubmed]
PHST- 2008/02/21 09:00 [medline]
PHST- 2008/01/30 09:00 [entrez]
AID - ncpneph0674 [pii]
AID - 10.1038/ncpneph0674 [doi]
PST - ppublish
SO  - Nat Clin Pract Nephrol. 2008 Feb;4(2):110-4. doi: 10.1038/ncpneph0674.