PMID- 18227938 OWN - NLM STAT- MEDLINE DCOM- 20080710 LR - 20211027 IS - 0003-2654 (Print) IS - 0003-2654 (Linking) VI - 133 IP - 2 DP - 2008 Feb TI - Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry. PG - 175-9 LID - 10.1039/b712853c [doi] AB - This communication utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with multivariate analysis to obtain spectra from the surfaces of three closely related cell lines allowing their discrimination based upon mass spectral ions. FAU - Baker, Matthew J AU - Baker MJ AD - Manchester Interdisciplinary Biocentre, Centre for Instrumentation and Analytical Science, School of Chemical Engineering and Analytical Science, The University of Manchester, UK. M.Baker-2@postgrad.manchester.ac.uk FAU - Brown, Michael D AU - Brown MD FAU - Gazi, Ehsan AU - Gazi E FAU - Clarke, Noel W AU - Clarke NW FAU - Vickerman, John C AU - Vickerman JC FAU - Lockyer, Nicholas P AU - Lockyer NP LA - eng GR - G0500966/MRC_/Medical Research Council/United Kingdom GR - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20071130 PL - England TA - Analyst JT - The Analyst JID - 0372652 SB - IM MH - Cell Line, Tumor MH - Discriminant Analysis MH - Humans MH - Male MH - Principal Component Analysis/methods MH - Prostatic Neoplasms/*diagnosis MH - Spectrometry, Mass, Secondary Ion/*methods EDAT- 2008/01/30 09:00 MHDA- 2008/07/11 09:00 CRDT- 2008/01/30 09:00 PHST- 2008/01/30 09:00 [pubmed] PHST- 2008/07/11 09:00 [medline] PHST- 2008/01/30 09:00 [entrez] AID - 10.1039/b712853c [doi] PST - ppublish SO - Analyst. 2008 Feb;133(2):175-9. doi: 10.1039/b712853c. Epub 2007 Nov 30.