PMID- 18230355
OWN - NLM
STAT- MEDLINE
DCOM- 20080603
LR  - 20080303
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 390
IP  - 1-2
DP  - 2008 Apr
TI  - Association between the -2518G/A polymorphism in the monocyte chemoattractant 
      protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients.
PG  - 122-5
LID - 10.1016/j.cca.2008.01.004 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1; gene name CCL2) has been 
      suggested to play an important role in the initiation of atherosclerosis by 
      recruiting monocytes to sites of injured endothelium. Recently, single nucleotide 
      polymorphisms (SNPs) in the MCP-1 regulatory region have been identified. 
      Controversial results regarding the association of the -2518G/A polymorphism of 
      the MCP-1 gene with coronary artery disease (CAD) have been reported. In the 
      present study, we examined a possible association between the -2518G/A 
      polymorphism of the MCP-1 gene and myocardial infarction (MI) in a sample of the 
      Tunisian population. METHODS: A total of 319 Tunisian patients with MI and 467 
      healthy controls were included in the study. The SNP of the MCP-1 gene was 
      determined by polymerase chain reaction-restriction fragment length polymorphism 
      (PCR-RFLP) analysis. RESULTS: Patients with MI had significantly higher frequency 
      of the AG+GG genotypes compared to controls [42.9% vs. 35.8%; OR (95%CI), 1.34 
      (1.00-1.79); p=0.04]. The MI patient group showed a significant higher frequency 
      of the G allele compared to the controls [0.242 vs. 0.195; OR (95%CI), 
      1.31(1.02-1.68), p=0.03]. The association between the -2518G/A polymorphism of 
      the MCP-1 gene and MI was no longer significant after adjustment for other 
      well-established risk factors. CONCLUSION: The present study showed a significant 
      but not independent association between the -2518G/A polymorphism of the MCP-1 
      gene (presence of G allele) and MI in the Tunisian population.
FAU - Jemaa, Riadh
AU  - Jemaa R
AD  - Research Laboratory LAB-SM-01, Department of Biochemistry, Hospital la Rabta, 
      Tunis, Tunisia. jemaa_riadh@yahoo.fr
FAU - Rojbani, Hajer
AU  - Rojbani H
FAU - Kallel, Amani
AU  - Kallel A
FAU - Ben Ali, Samir
AU  - Ben Ali S
FAU - Feki, Moncef
AU  - Feki M
FAU - Chabrak, Sonia
AU  - Chabrak S
FAU - Elasmi, Monia
AU  - Elasmi M
FAU - Taieb, Samah Haj
AU  - Taieb SH
FAU - Sanhaji, Haifa
AU  - Sanhaji H
FAU - Souheil, Omar
AU  - Souheil O
FAU - Mechmeche, Rachid
AU  - Mechmeche R
FAU - Kaabachi, Naziha
AU  - Kaabachi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080116
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
SB  - IM
MH  - Base Sequence
MH  - Chemokine CCL2/*genetics
MH  - DNA Primers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Tunisia
EDAT- 2008/01/31 09:00
MHDA- 2008/06/05 09:00
CRDT- 2008/01/31 09:00
PHST- 2007/11/12 00:00 [received]
PHST- 2008/01/08 00:00 [revised]
PHST- 2008/01/08 00:00 [accepted]
PHST- 2008/01/31 09:00 [pubmed]
PHST- 2008/06/05 09:00 [medline]
PHST- 2008/01/31 09:00 [entrez]
AID - S0009-8981(08)00017-X [pii]
AID - 10.1016/j.cca.2008.01.004 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2008 Apr;390(1-2):122-5. doi: 10.1016/j.cca.2008.01.004. Epub 
      2008 Jan 16.