PMID- 18230690
OWN - NLM
STAT- MEDLINE
DCOM- 20080415
LR  - 20141120
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Linking)
VI  - 61
IP  - 4
DP  - 2008 Apr
TI  - Clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with 
      VanD phenotype and vanA genotype.
PG  - 838-44
LID - 10.1093/jac/dkn025 [doi]
AB  - OBJECTIVES: To investigate the clinical implications of vancomycin-resistant 
      Enterococcus faecium (VRE) with VanD phenotype and vanA genotype (VanD-vanA VRE). 
      METHODS: We tested in vitro and in vivo efficacies of teicoplanin against 
      VanD-vanA VRE strains. Change in teicoplanin MICs was monitored during incubation 
      with teicoplanin. In vitro and in vivo time-kill assay and survival analysis 
      using a mouse peritonitis model were performed. RESULTS: Teicoplanin MICs of 
      VanD-vanA VRE strains increased to 128 mg/L within 48 h when they were cultured 
      with 120 mg/L teicoplanin. In vitro and in vivo time-kill assay showed that 
      VanD-vanA VRE strains were not eliminated by 120 mg/L teicoplanin in contrast to 
      vancomycin-susceptible E. faecium and VanD-vanB strains. The survival rate of 
      mice infected with VanD-vanA VRE strains treated with teicoplanin was comparable 
      with that of untreated mice. CONCLUSION: Data suggest that teicoplanin would fail 
      in the treatment of VanD type VRE infections if the strains contained the vanA 
      gene, which cannot be detected in the clinical microbiology laboratory.
FAU - Song, Jae-Hoon
AU  - Song JH
AD  - Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea. jhsong@ansorp.org
FAU - Ko, Kwan Soo
AU  - Ko KS
FAU - Suh, Ji Yoeun
AU  - Suh JY
FAU - Oh, Won Sup
AU  - Oh WS
FAU - Kang, Cheol-In
AU  - Kang CI
FAU - Chung, Doo Ryeon
AU  - Chung DR
FAU - Peck, Kyong Ran
AU  - Peck KR
FAU - Lee, Nam Yong
AU  - Lee NY
FAU - Lee, Wee Gyo
AU  - Lee WG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080129
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bacterial Proteins)
RN  - 0 (VanA ligase, Bacteria)
RN  - 61036-62-2 (Teicoplanin)
RN  - EC 6.1.- (Carbon-Oxygen Ligases)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology/*therapeutic use
MH  - Bacterial Proteins/*genetics
MH  - Blood/microbiology
MH  - Carbon-Oxygen Ligases/*genetics
MH  - Colony Count, Microbial
MH  - Enterococcus faecium/*drug effects/genetics/isolation & purification
MH  - Female
MH  - Gram-Positive Bacterial Infections/drug therapy/microbiology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Microbial Sensitivity Tests
MH  - Microbial Viability
MH  - Peritonitis/drug therapy/microbiology
MH  - Survival Analysis
MH  - Teicoplanin/*pharmacology/*therapeutic use
MH  - Vancomycin Resistance/*genetics
EDAT- 2008/01/31 09:00
MHDA- 2008/04/16 09:00
CRDT- 2008/01/31 09:00
PHST- 2008/01/31 09:00 [pubmed]
PHST- 2008/04/16 09:00 [medline]
PHST- 2008/01/31 09:00 [entrez]
AID - dkn025 [pii]
AID - 10.1093/jac/dkn025 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2008 Apr;61(4):838-44. doi: 10.1093/jac/dkn025. Epub 2008 
      Jan 29.