PMID- 1823259
OWN - NLM
STAT- MEDLINE
DCOM- 19920922
LR  - 20161018
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 24
IP  - 5
DP  - 1991
TI  - Age-related changes of glutathione content, glutathione reductase and glutathione 
      peroxidase activity of human erythrocytes.
PG  - 449-54
AB  - 1. In order to investigate the effect of aging on the erythrocyte glutathione 
      system, total glutathione (GSH), glutathione reductase (GSH-red) and glutathione 
      peroxidase (GSH-px) levels were measured in erythrocytes from 33 young (mean age 
      = 30.5 +/- 9.7 years) and 28 aged (mean age = 68.9 +/- 11.4 years) healthy 
      individuals. 2. GSH was 3.5 +/- 1.8 microM/g Hb for the young group, a value 
      significantly greater (P less than 0.01) than 2.3 +/- 0.9 microM/g Hb found for 
      the aged group. Similarly, GSH-red activity, 5.5 +/- 1.8 IU/g Hb, was higher (P 
      less than 0.05) for the young group than 3.4 +/- 0.9 IU/g Hb found for the aged 
      group. The GSH-px activity levels for the young group, 21.1 +/- 5.9 IU/g Hb, were 
      significantly greater (P less than 0.01) than 12.0 +/- 3.3 IU/g Hb for the aged 
      group. The lower activity detected in the aged group for all of these parameters 
      of the glutathione redox system was not related to low levels of hematocrit or 
      hemoglobin. 3. There was no statistical difference in the activation coefficient 
      (AC) of reductase (+FAD/-FAD) between groups, which seems to indicate that the 
      lower activity of glutathione reductase observed in the aged group was not due to 
      riboflavin deficiency. 4. Additional information is required to determine the 
      mechanisms controlling the glutathione redox system and its role in the aging 
      process.
FAU - Matsubara, L S
AU  - Matsubara LS
AD  - Departamento de Clinica Medica, Faculdade de Medicina de Botucatu, Universidade 
      Estadual Paulista, SP, Brasil.
FAU - Machado, P E
AU  - Machado PE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Aged
MH  - Aging/*blood
MH  - Erythrocyte Indices
MH  - Erythrocytes/*chemistry/enzymology
MH  - Glutathione/*analysis
MH  - Glutathione Peroxidase/*analysis
MH  - Glutathione Reductase/*analysis
MH  - Humans
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Braz J Med Biol Res. 1991;24(5):449-54.