PMID- 1823283
OWN - NLM
STAT- MEDLINE
DCOM- 19920922
LR  - 20161018
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 24
IP  - 6
DP  - 1991
TI  - Effect of central administration of serotoninergic agonists on electrolyte 
      excretion control.
PG  - 633-41
AB  - 1. The participation of different central serotoninergic (5HT) receptors in the 
      mediation of Na+ excretion (UNaV), K+ excretion (UKV) and urine output (UV) was 
      evaluated. 2. Male Wistar rats weighing 220-280 g were used in each group of 9-18 
      animals. The rats were injected intracerebroventricularly (icv) with the 5HT 
      agonists MK212 (1.5, 15.0 and 30.0 micrograms), 8-OH-DPAT (5.0 and 15.0 
      micrograms), 5HT (2.5, 12.5 and 25.0 micrograms) and DOI (10.0 and 25.0 
      micrograms). 3. At the lowest MK212 dose, UNaV was significantly reduced (0.18 
      +/- 0.04 microEq/min vs 0.35 +/- 0.04 microEq/min for saline) at 20 min. At the 
      highest dose, MK212 provoked a significant increase in UNaV (0.60 +/- 0.06 
      microEq/min vs 0.34 +/- 0.03 microEq/min for saline) at 40 min. UKV values were 
      significantly modified only at the 1.5-micrograms dose (0.18 +/- 0.04 microEq/min 
      vs 0.35 +/- 0.04 microEq/min for saline) at 20 min. 4. Icv injection of 8-OH-DPAT 
      provoked a significant reduction in UNaV (0.16 +/- 0.05 microEq/min vs 0.35 +/- 
      0.03 microEq/min for saline) and UKV (0.15 +/- 0.05 microEq/min vs 0.34 +/- 0.02 
      microEq/min for saline) at 40 min both doses. 5. Icv injection of 5HT at the 
      highest dose provoked a significant increase in UNaV (0.92 +/- 0.10 microEq/min 
      vs 0.33 +/- 0.04 microEq/min for saline) and in UKV (0.55 +/- 0.08 microEq/min vs 
      0.24 +/- 0.07 microEq/min for saline) at 40 min. 6. Icv administration of DOI 
      caused a natriuretic response (0.69 +/- 0.12 microEq/min vs 0.31 +/- 0.04 
      microEq/min for saline) at 40 min, with no significant effect on UKV.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Reis, L C
AU  - Reis LC
AD  - Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, Brasil.
FAU - Ramalho, M J
AU  - Ramalho MJ
FAU - Antunes-Rodrigues, J
AU  - Antunes-Rodrigues J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Receptors, Serotonin)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Diuresis/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Potassium/*urine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/*drug effects
MH  - Sodium/*urine
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Braz J Med Biol Res. 1991;24(6):633-41.