PMID- 18234052
OWN - NLM
STAT- MEDLINE
DCOM- 20080307
LR  - 20220408
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 151
IP  - 3
DP  - 2008 Mar
TI  - BDCA-1+, BDCA-2+ and BDCA-3+ dendritic cells in early human pregnancy decidua.
PG  - 399-406
LID - 10.1111/j.1365-2249.2007.03576.x [doi]
AB  - Dendritic cells (DCs) can acquire unique features or phenotypes in different 
      tissue microenvironments and decide whether immunity or tolerance develops. DCs 
      observed within the decidua have been implicated in pregnancy maintenance. 
      However, the precise distribution of decidual DC subsets and their phenotypic 
      characteristics are largely unknown. Using flow cytometry, we identified three DC 
      subsets in normal human first-trimester decidua: BDCA-1+ CD19- CD14(-) myeloid DC 
      type 1 (MDC1), BDCA-3+ CD14- myeloid DC type 2 (MDC2) and BDCA-2+ CD123+ 
      plasmacytoid DC (PDC). The percentage of MDC1 to mononuclear cells in the decidua 
      was similar to that in the peripheral blood controls. The percentage of MDC2 in 
      the decidua was significantly higher than that in the peripheral blood controls, 
      whereas the percentage of PDC was significantly lower. Both MDC1 and MDC2 subsets 
      expressed human leucocyte antigen D-related, CD86 and CD80 at low levels, 
      suggesting a characteristic of immature myeloid DCs. Immunoglobulin-like 
      transcript 3, suggested to be involved in immune tolerance induction, was also 
      expressed on decidual MDC1 and MDC2 subsets. In addition, as gestational age 
      increased from 6 to 9 weeks, the numbers of MDC1 decreased but MDC2 increased 
      significantly. This is the first study to demonstrate the presence of three 
      previously unidentified BDCA-1+, BDCA-3+ and BDCA-2+ DC subsets in human decidua, 
      these decidual DCs might play important role in the maintenance of pregnancy.
FAU - Ban, Y-L
AU  - Ban YL
AD  - Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 
      Ji'nan, Shandong, China.
FAU - Kong, B-H
AU  - Kong BH
FAU - Qu, X
AU  - Qu X
FAU - Yang, Q-F
AU  - Yang QF
FAU - Ma, Y-Y
AU  - Ma YY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, Surface)
RN  - 0 (CD1C protein, human)
RN  - 0 (CLEC4C protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (LILRB4 protein, human)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (THBD protein, human)
RN  - 0 (Thrombomodulin)
SB  - IM
MH  - Antigens, CD1
MH  - Antigens, Surface/*metabolism
MH  - Decidua/*immunology
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Gestational Age
MH  - Glycoproteins
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Immunophenotyping
MH  - Lectins, C-Type/metabolism
MH  - Membrane Glycoproteins/metabolism
MH  - Pregnancy/*immunology
MH  - Receptors, Cell Surface/metabolism
MH  - Receptors, Immunologic/metabolism
MH  - Thrombomodulin
PMC - PMC2276959
EDAT- 2008/02/01 09:00
MHDA- 2008/03/08 09:00
PMCR- 2009/03/01
CRDT- 2008/02/01 09:00
PHST- 2008/02/01 09:00 [pubmed]
PHST- 2008/03/08 09:00 [medline]
PHST- 2008/02/01 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - CEI3576 [pii]
AID - 10.1111/j.1365-2249.2007.03576.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2008 Mar;151(3):399-406. doi: 10.1111/j.1365-2249.2007.03576.x.