PMID- 18235216
OWN - NLM
STAT- MEDLINE
DCOM- 20080731
LR  - 20191210
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Linking)
VI  - 8
IP  - 1
DP  - 2008
TI  - Monocyte chemoattractant protein 1, active carboxypeptidase B and CAPAP at 
      hospital admission are predictive markers for severe acute pancreatitis.
PG  - 42-9
LID - 10.1159/000114866 [doi]
AB  - BACKGROUND: CAPAP, the activation peptide of procarboxypeptidase B, is a 
      predictor of severe acute pancreatitis (AP). Active carboxypeptidase (aCAP) may 
      be a better predictor, as its turnover is slower. Monocyte chemotactic protein-1 
      (MCP-1) is an early inflammatory marker and increases before complications in 
      severe AP. We conducted a cohort study to evaluate these markers as predictors 
      for severe AP. METHOD: 140 patients with AP were included, retrospectively 
      grouped as severe or mild by the Atlanta classification. CAPAP, MCP-1 and aCAP 
      were analyzed in admission samples. Receiver operating characteristic curves 
      determined high vs. low levels. RESULTS: The levels of all markers were 
      significantly higher in patients with severe disease. High levels of serum MCP-1 
      was associated with a high risk of developing severe AP (OR 40.8; 95% CI 
      8.5-195). High ORs were also seen for urine MCP-1 (OR 7.3; 95% CI 2.2-24.3), 
      serum CAPAP (OR 5.4; 95% CI 1.6-17.7), urine CAPAP (OR 4.8; 95% CI 1.6-14.2), and 
      serum aCAP (OR 3.7; 95% CI 1.2-11.3). CONCLUSION: Serum MCP-1 at admission was 
      strongly associated with development of severe AP. MCP-1 in urine, CAPAP in serum 
      and urine and aCAP may also be useful for predicting severe AP. and IAP.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Regner, S
AU  - Regner S
AD  - Department of Surgery, Malmo University Hospital, Lund University, Lund, Sweden. 
      sara.regner@med.lu.se
FAU - Appelros, S
AU  - Appelros S
FAU - Hjalmarsson, C
AU  - Hjalmarsson C
FAU - Manjer, J
AU  - Manjer J
FAU - Sadic, J
AU  - Sadic J
FAU - Borgstrom, A
AU  - Borgstrom A
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20080131
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Peptides)
RN  - 0 (carboxypeptidase B activation peptide)
RN  - EC 3.4.17.2 (Carboxypeptidase B)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers
MH  - Carboxypeptidase B/*blood
MH  - Chemokine CCL2/*blood
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*blood
MH  - Peptides/*blood
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2008/02/01 09:00
MHDA- 2008/08/01 09:00
CRDT- 2008/02/01 09:00
PHST- 2007/07/02 00:00 [received]
PHST- 2007/10/05 00:00 [accepted]
PHST- 2008/02/01 09:00 [pubmed]
PHST- 2008/08/01 09:00 [medline]
PHST- 2008/02/01 09:00 [entrez]
AID - S1424-3903(08)80025-7 [pii]
AID - 10.1159/000114866 [doi]
PST - ppublish
SO  - Pancreatology. 2008;8(1):42-9. doi: 10.1159/000114866. Epub 2008 Jan 31.