PMID- 18235400
OWN - NLM
STAT- MEDLINE
DCOM- 20080521
LR  - 20080131
IS  - 0761-8425 (Print)
IS  - 0761-8425 (Linking)
VI  - 24
IP  - 8 Pt 2
DP  - 2007 Oct
TI  - [Combination of chemotherapy and radiotherapy for locally advanced non-small cell 
      lung cancer].
PG  - 6S94-100
AB  - Despite the progress in therapeutic strategies, overall survival of stage III non 
      small cell lung cancers (NSCLC) is poor. Currently, the standard treatment for 
      unresectable locally advanced NSCLC is concurrent chemoradiotherapy. However, 
      oesophagitis is a major toxicity and this schedule should be reserved for 
      patients with good performance status. Several platinum-based chemotherapies have 
      been evaluated concurrently with radiotherapy and cisplatin-etoposide regimen 
      remains the standard because full dose chemotherapy can be administered. 
      Cisplatin-vinorelbine offers a good efficacy/toxicity profile. The optimal 
      sequencing of concurrent chemoradiotherapy and chemotherapy is not well defined. 
      Consolidation chemotherapy with docetaxel failed to show a better outcome. The 
      new technologies in radiotherapy and dose escalation will certainly improve the 
      efficacy of chemoradiotherapy and reduce toxicity. The integration of targeted 
      therapies in the management of stage III NSCLC is also under investigation.
FAU - Fournel, P
AU  - Fournel P
AD  - Departement d'Oncologie Medicale, Institut de Cancerologie de Loire, 
      Saint-Priest-en-Jarez cedex, France. peirre.fournel@icloire.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Articulation de la chimiotherapie avec la radiotherapie dans les stades 
      localement avances du CBNPC.
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/pathology/*radiotherapy
MH  - Combined Modality Therapy
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/pathology/*radiotherapy
MH  - Neoplasm Staging
RF  - 21
EDAT- 2008/02/22 09:00
MHDA- 2008/05/22 09:00
CRDT- 2008/02/22 09:00
PHST- 2008/02/22 09:00 [pubmed]
PHST- 2008/05/22 09:00 [medline]
PHST- 2008/02/22 09:00 [entrez]
AID - MDOI-RMR-10-2007-24-8-C2-0761-8425-101019-200720135 [pii]
PST - ppublish
SO  - Rev Mal Respir. 2007 Oct;24(8 Pt 2):6S94-100.