PMID- 182380
OWN - NLM
STAT- MEDLINE
DCOM- 19761101
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 8
IP  - 1
DP  - 1976 May
TI  - High frequency variation in mammary tumor virus expression in cell culture.
PG  - 87-93
AB  - Clonal derivatives of C3HMT murine mammary cell lines in culture demonstrate 
      conversion of mammary tumor virus (MMTV) expression at a rate of appriximately 6 
      per 100 clones. This alteration is largely unidirectional from a relatively high 
      level (MMTV(H)) to a 10 fold lower level (MMTV(L)). This high rate of MMTV(L) 
      variant conversion is in apparent contrast to the presumably mutational rate 
      (approximately 3 per million cells) that governs development of resistance to 
      6-thioguanine (TG) in the same mammary cells. In somatic cell hybrids between 
      different MMTV TGr clones and mouse or hamster TK- cells, expression of 
      constitutive levels of MMTV and responsiveness to dexamethasone induction is 
      dominant. Thus MMTV expression is regulated by at least two levels of positive 
      control, constitutive expression and glucocorticoid stimulation, but the former 
      is subject to a high rate of variant formation.
FAU - Parks, W P
AU  - Parks WP
FAU - Hubbell, E S
AU  - Hubbell ES
FAU - Goldberg, R J
AU  - Goldberg RJ
FAU - O'Neill, F J
AU  - O'Neill FJ
FAU - Scolnick, E M
AU  - Scolnick EM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Viral Proteins)
RN  - 12H3O2UGSF (Methylnitronitrosoguanidine)
RN  - FTK8U1GZNX (Thioguanine)
SB  - IM
MH  - Cell Line
MH  - Clone Cells
MH  - Drug Resistance
MH  - *Genes, Dominant
MH  - *Genetic Variation
MH  - Hybrid Cells
MH  - Karyotyping
MH  - *Mammary Tumor Virus, Mouse
MH  - Methylnitronitrosoguanidine/pharmacology
MH  - Thioguanine/pharmacology
MH  - Viral Proteins/biosynthesis
EDAT- 1976/05/01 00:00
MHDA- 1976/05/01 00:01
CRDT- 1976/05/01 00:00
PHST- 1976/05/01 00:00 [pubmed]
PHST- 1976/05/01 00:01 [medline]
PHST- 1976/05/01 00:00 [entrez]
AID - 0092-8674(76)90189-6 [pii]
AID - 10.1016/0092-8674(76)90189-6 [doi]
PST - ppublish
SO  - Cell. 1976 May;8(1):87-93. doi: 10.1016/0092-8674(76)90189-6.