PMID- 1824048
OWN - NLM
STAT- MEDLINE
DCOM- 19920327
LR  - 20191028
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 241
IP  - 3
DP  - 1991
TI  - Predictors of response to monoamine oxidase inhibitors: do they exist?
PG  - 181-6
AB  - Multiple regression analysis was conducted on potential response predictors in a 
      double-blind study of monoamine oxidase inhibitors (MAOI) and placebo treatment 
      in 130 depressed outpatients. Positive main effects were found for sex (female), 
      lack of prior hospitalization, presence of precipitating events. A negative main 
      effect was found for concurrent physical illness. Treatment x predictor effects 
      were found for distinct quality and non-reactivity. Non-reactivity was associated 
      with positive outcome in the active drug group, but with negative outcome in the 
      placebo group [corrected]. Distinct quality demonstrated a more complex effect, 
      its presence being associated with decreased improvement in the treatment group 
      and greater improvement in the control group. No atypical depressive symptoms 
      predicted MAOI response, and we were unable to characterize a specifically 
      responsive MAOI syndrome.
FAU - Davidson, J R
AU  - Davidson JR
AD  - Duke University Medical Center, Durham, NC 27710.
FAU - Giller, E L
AU  - Giller EL
FAU - Zisook, S
AU  - Zisook S
FAU - Helms, M J
AU  - Helms MJ
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 34237V843T (Isocarboxazid)
SB  - IM
EIN - Eur Arch Psychiatry Clin Neurosci 1992;241(6):376
MH  - Adult
MH  - Depressive Disorder/*drug therapy/*psychology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Isocarboxazid/therapeutic use
MH  - Male
MH  - Models, Statistical
MH  - Monoamine Oxidase Inhibitors/*therapeutic use
MH  - Psychiatric Status Rating Scales/*statistics & numerical data
MH  - Psychometrics
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1007/BF02219719 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 1991;241(3):181-6. doi: 10.1007/BF02219719.