PMID- 18241684
OWN - NLM
STAT- MEDLINE
DCOM- 20080312
LR  - 20080204
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
VI  - 121
IP  - 2 Suppl
DP  - 2008 Feb
TI  - 2. Dendritic cells as regulators of immunity and tolerance.
PG  - S370-4; quiz S413
LID - 10.1016/j.jaci.2007.06.001 [doi]
AB  - Dendritic cells (DCs) are antigen sampling sentinels of the peripheral tissue and 
      specialists for antigen capture, processing, and presentation to T cells as well 
      as T-cell priming. By virtue of their mission as antigen samplers, they populate 
      the body surfaces that line the border of our organism with the environment such 
      as the skin and the mucosa of the respiratory and the gastrointestinal tract. 
      Although all DCs share some classic features, their individual organ-specific 
      phenotype and function are ascertained by a complex, dynamic network of 
      co-regulatory factors provided by their microenvironment. DC subtypes might 
      initiate novel inflammatory immune responses as well as accelerate or break down 
      ongoing inflammatory immune reactions in the skin, the gut, and the respiratory 
      tract. On the basis of the recognition of self-signals or nonself-signals in the 
      presence or absence of danger signals, the interplay of DC antigen uptake and 
      presentation leads into immunosilencing or immunoactivating properties, which 
      designate the outcome of tolerance or defensive immunity within the skin, the 
      gut, or the respiratory tree.
FAU - Novak, Natalija
AU  - Novak N
AD  - Department of Dermatology, University of Bonn, Bonn, Germany. 
      Natalija.Novak@ukb.uni-bonn.de
FAU - Bieber, Thomas
AU  - Bieber T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Antigens)
SB  - IM
MH  - Antigens/metabolism
MH  - Dendritic Cells/metabolism/*physiology
MH  - Humans
MH  - Immune Tolerance/*physiology
MH  - Immunity/*physiology
MH  - Intestinal Mucosa/cytology
MH  - Lung/cytology
MH  - Skin/cytology
RF  - 27
EDAT- 2008/02/05 09:00
MHDA- 2008/03/13 09:00
CRDT- 2008/02/05 09:00
PHST- 2007/04/15 00:00 [received]
PHST- 2007/05/31 00:00 [revised]
PHST- 2007/06/01 00:00 [accepted]
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/03/13 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0091-6749(07)01043-3 [pii]
AID - 10.1016/j.jaci.2007.06.001 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2008 Feb;121(2 Suppl):S370-4; quiz S413. doi: 
      10.1016/j.jaci.2007.06.001.