PMID- 1824171
OWN - NLM
STAT- MEDLINE
DCOM- 19921014
LR  - 20170214
IS  - 0192-6233 (Print)
IS  - 0192-6233 (Linking)
VI  - 19
IP  - 4 Pt 2
DP  - 1991
TI  - Toxic interactions in the rat nose: pollutants from soiled bedding and methyl 
      bromide.
PG  - 571-9
AB  - Interactions between test chemicals and pollutants can confound toxicology 
      studies. To test the sensitivity of the regenerating olfactory epithelium to 
      additional challenge with the olfactory epithelial toxicant methyl bromide 
      (MeBr), Fischer 344 (F344) rats received 2 6-hr inhalation exposures (separated 
      by a 28-day recovery period) to either 0 or 175 ppm MeBr. The regenerating 
      epithelium was resistant to the second MeBr exposure. In addition, 
      histopathologic examination revealed squamous epithelial hyperplasia in the 
      vestibule; inflammation, epithelial necrosis, mucosal erosions, and squamous 
      metaplasia of the respiratory epithelium in the anterior nose; and olfactory 
      sensory cell loss in the dorsal medial meatus. These changes could not be 
      attributed to MeBr, but they were correlated with housing in filter-capped cages 
      between MeBr exposures and were presumably caused by volatile pollutants from 
      soiled bedding. Moreover, olfactory sensory cell loss in the dorsal medial meatus 
      was associated with local resistance to MeBr-induced damage in rats with 
      pollutant-induced changes. Analysis of cage air revealed a progressive increase 
      in ammonia levels between bedding changes (up to 50 ppm), but exposure to 300 ppm 
      ammonia in an additional experiment reproduced only the anterior nasal lesions 
      and not olfactory sensory cell loss. This study demonstrates that 1) regenerating 
      olfactory epithelium is refractory to further MeBr toxicity; 2) pollutants from 
      soiled bedding (in addition to ammonia) produce nasal lesions; and 3) 
      pollutant-induced changes modify the nasal response to inhaled MeBr.
FAU - Bolon, B
AU  - Bolon B
AD  - Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 
      27709.
FAU - Bonnefoi, M S
AU  - Bonnefoi MS
FAU - Roberts, K C
AU  - Roberts KC
FAU - Marshall, M W
AU  - Marshall MW
FAU - Morgan, K T
AU  - Morgan KT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Pathol
JT  - Toxicologic pathology
JID - 7905907
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 7664-41-7 (Ammonia)
RN  - 9V42E1Z7B6 (methyl bromide)
SB  - IM
MH  - Administration, Inhalation
MH  - Ammonia/toxicity
MH  - Animals
MH  - Drug Interactions
MH  - Environmental Pollutants/*toxicity
MH  - Feces
MH  - *Housing, Animal
MH  - Hydrocarbons, Brominated/administration & dosage/*toxicity
MH  - Male
MH  - Nasal Cavity/*drug effects/pathology
MH  - Nasal Mucosa/drug effects
MH  - Olfactory Mucosa/*drug effects
MH  - Rats
MH  - Rats, Inbred F344
MH  - Urine
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1177/019262339101900402 [doi]
PST - ppublish
SO  - Toxicol Pathol. 1991;19(4 Pt 2):571-9. doi: 10.1177/019262339101900402.