PMID- 18242852 OWN - NLM STAT- MEDLINE DCOM- 20080612 LR - 20131121 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 433 IP - 2 DP - 2008 Mar 12 TI - Association of the brain-derived neurotrophic factor gene and bipolar disorder with early age of onset in mainland China. PG - 98-102 LID - 10.1016/j.neulet.2008.01.001 [doi] AB - Several evidences have suggested that the brain-derived neurotrophic factor (BDNF) gene may be involved in the pathogenesis of bipolar disorder (BPD), but not all studies get the same result. The paper investigated two genetic polymorphisms of BDNF, C-270T and Val66Met, in a case-control design for their association with BPD. Sixty-seven patients of early age of onset and 130 patients of late age of onset were selected for study and 208 healthy individuals were used as controls. No significantly statistical differences of these two polymorphisms were found in genotypes or allele frequencies between either overall patients or late age of onset patients and normal control subjects. However, the frequency of the Val allele of the Val66Met polymorphism was found to have significantly increased in the subgroup patients with early age of onset as compared with the controls (genotype: chi(2)=6.602, d.f.=2, P=0.037; allele: chi(2)=6.223, d.f.=1, P=0.015). The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole. But Val66Met may be associated with susceptibility to the early age of onset subset of the disorder, further studies designed to explore the relationship in a larger population may be warranted. FAU - Tang, Jihua AU - Tang J AD - Department of Psychiatry, Renmin Hospital, Wuhan University, Jiefang Road 238#, Wuhan 430060, PR China. FAU - Xiao, Ling AU - Xiao L FAU - Shu, Chang AU - Shu C FAU - Wang, Gaohua AU - Wang G FAU - Liu, Zhongchun AU - Liu Z FAU - Wang, Xiaoping AU - Wang X FAU - Wang, Huiling AU - Wang H FAU - Bai, Xueguang AU - Bai X LA - eng PT - Journal Article DEP - 20080110 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - AE28F7PNPL (Methionine) RN - HG18B9YRS7 (Valine) SB - IM MH - Adult MH - Age of Onset MH - Bipolar Disorder/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - China/ethnology MH - Female MH - Gene Frequency MH - *Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Male MH - Methionine/genetics MH - Middle Aged MH - Polymorphism, Genetic/*genetics MH - Valine/genetics EDAT- 2008/02/05 09:00 MHDA- 2008/06/13 09:00 CRDT- 2008/02/05 09:00 PHST- 2007/09/30 00:00 [received] PHST- 2007/12/14 00:00 [revised] PHST- 2008/01/02 00:00 [accepted] PHST- 2008/02/05 09:00 [pubmed] PHST- 2008/06/13 09:00 [medline] PHST- 2008/02/05 09:00 [entrez] AID - S0304-3940(08)00023-2 [pii] AID - 10.1016/j.neulet.2008.01.001 [doi] PST - ppublish SO - Neurosci Lett. 2008 Mar 12;433(2):98-102. doi: 10.1016/j.neulet.2008.01.001. Epub 2008 Jan 10.