PMID- 18242855
OWN - NLM
STAT- MEDLINE
DCOM- 20080612
LR  - 20080229
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 433
IP  - 2
DP  - 2008 Mar 12
TI  - Association study of brain-derived neurotrophic factor and apolipoprotein E 
      polymorphisms and cognitive function in aged males without dementia.
PG  - 158-62
LID - 10.1016/j.neulet.2007.12.057 [doi]
AB  - Genetic factors for inter-individual variation in cognition have been arousing 
      great interest among researchers. Among the many associated genes, brain-derived 
      neurotrophic factor (BDNF) and apolipoprotein E (APOE), as two of the most 
      frequently studied, might be good prospects for cognitive genetics. Thus, the aim 
      of this study was to investigate both the isolated and cooperative effect of BDNF 
      and APOE on normal cognitive ageing. A homogeneous population of Chinese aged 
      males (N=161) were genotyped for functional genetic variants of BDNF (BDNF-G196A) 
      and APOE (APOE-epsilon4) and assessed by a comprehensive neuropsychological 
      measurement (Cognitive Abilities Screening Instrument Chinese version; CASI 
      C-2.0). Thereafter genotypic group differences of BDNF and APOE in CASI cognitive 
      profiles were tested. Results from the present study suggest the possible 
      influence of APOE on specific cognitive domains (CASI orientation and language 
      domains; p=0.010 and 0.028, respectively), whereas there was no significant role 
      of BDNF, either solely or with APOE, in cognition in the elderly. Our findings 
      suggest a possible association between APOE-epsilon4 and specific cognitive 
      domains in the aged male, whereas the functional genetic variant of BDNF 
      (BDNF-G196A) played no significant role in normal cognitive ageing.
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
AD  - Department of Psychiatry, Veterans General Hospital-Taipei, No. 201, Shih-Pai 
      Road, Sec. 2, 11217 Taipei, Taiwan. sjtsai@vghtpe.gov.tw
FAU - Gau, Yung-Tian A
AU  - Gau YT
FAU - Liu, Mu-En
AU  - Liu ME
FAU - Hsieh, Cheng-Hsi
AU  - Hsieh CH
FAU - Liou, Ying-Jay
AU  - Liou YJ
FAU - Hong, Chen-Jee
AU  - Hong CJ
LA  - eng
PT  - Journal Article
DEP - 20080110
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*genetics
MH  - Apolipoprotein E4/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition/*physiology
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Language
MH  - Male
MH  - Neuropsychological Tests
MH  - Orientation/physiology
MH  - Polymorphism, Genetic/*genetics
MH  - Taiwan
EDAT- 2008/02/05 09:00
MHDA- 2008/06/13 09:00
CRDT- 2008/02/05 09:00
PHST- 2007/11/02 00:00 [received]
PHST- 2007/12/19 00:00 [revised]
PHST- 2007/12/31 00:00 [accepted]
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/06/13 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0304-3940(08)00035-9 [pii]
AID - 10.1016/j.neulet.2007.12.057 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Mar 12;433(2):158-62. doi: 10.1016/j.neulet.2007.12.057. Epub 
      2008 Jan 10.