PMID- 18243226
OWN - NLM
STAT- MEDLINE
DCOM- 20080421
LR  - 20131121
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1183
IP  - 1-2
DP  - 2008 Mar 7
TI  - Rapid screening of methamphetamines in human serum by headspace solid-phase 
      microextraction using a dodecylsulfate-doped polypyrrole film coupled to ion 
      mobility spectrometry.
PG  - 21-8
LID - 10.1016/j.chroma.2008.01.020 [doi]
AB  - A simple, rapid and highly sensitive method for simultaneous analysis of 
      methamphetamine (MA) and 3,4-methylenedioxy methamphetamine (MDMA) in human serum 
      was developed using the solid-phase microextraction (SPME) combined with ion 
      mobility spectrometry (IMS). A dodecylsulfate-doped polypyrrole (PPy-DS) was 
      applied as a new fiber for SPME. Electrochemically polymerized PPy is formed on 
      the surface of a platinum wire and will contain charge-compensating anion 
      (dodecylsulfate) incorporated during synthesis using cyclic voltammetry (CV) 
      technique. The extraction properties of the fiber to MA and MDMA were examined, 
      using a headspace-SPME (HS-SPME) device and thermal desorption in injection port 
      of IMS. The results show that PPy-DS as a SPME fiber coating is suitable for the 
      successful extraction of these compounds. This method is suitable for the 
      identification and determination of MAs, is not time-consuming, requires small 
      quantities of sample and does not require any derivatization. Parameters like pH, 
      extraction time, ionic strength, and temperature of the sample were studied and 
      optimized to obtain the best extraction results. The HS-SPME-IMS method provided 
      good repeatability (RSDs<7.8 %) for spiked serum samples. The calibration graphs 
      were linear in the range of 20-4000 ng ml(-1) (R(2)>0.99) and detection limits 
      for MDMA and MA were 5 and 8 ng ml(-1), respectively. HS-SPME-IMS of non-spiked 
      serum sample provided a spectrum without any peak from the matrix, supporting an 
      effective sample clean-up. Finally, the proposed method was applied for analysis 
      one of the ecstasy tablet.
FAU - Alizadeh, Naader
AU  - Alizadeh N
AD  - Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, 
      Iran. alizaden@modares.ac.ir
FAU - Mohammadi, Abdorreza
AU  - Mohammadi A
FAU - Tabrizchi, Mahmoud
AU  - Tabrizchi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080116
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Ions)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Polymers)
RN  - 0 (Pyrroles)
RN  - 30604-81-0 (polypyrrole)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Electrochemistry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Ions/chemistry
MH  - Membranes, Artificial
MH  - Methamphetamine/*blood
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*blood
MH  - Polymers/chemistry
MH  - Pyrroles/chemistry
MH  - Sensitivity and Specificity
MH  - Sodium Dodecyl Sulfate/chemistry
MH  - Solid Phase Microextraction/*methods
MH  - Spectrum Analysis
MH  - Temperature
EDAT- 2008/02/05 09:00
MHDA- 2008/04/22 09:00
CRDT- 2008/02/05 09:00
PHST- 2007/08/13 00:00 [received]
PHST- 2008/01/05 00:00 [revised]
PHST- 2008/01/08 00:00 [accepted]
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/04/22 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0021-9673(08)00056-3 [pii]
AID - 10.1016/j.chroma.2008.01.020 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Mar 7;1183(1-2):21-8. doi: 10.1016/j.chroma.2008.01.020. 
      Epub 2008 Jan 16.