PMID- 18243551
OWN - NLM
STAT- MEDLINE
DCOM- 20080618
LR  - 20161124
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 434
IP  - 2
DP  - 2008 Mar 28
TI  - Comparison of blood-nerve barrier disruption and matrix metalloprotease-9 
      expression in injured central and peripheral nerves in mice.
PG  - 155-9
LID - 10.1016/j.neulet.2007.12.052 [doi]
AB  - To investigate the involvement of blood-born factors and extracellular proteases 
      in axonal degeneration and regeneration in both PNS and CNS, we directly compared 
      the differences of blood-nerve barrier (BNB) disruption and matrix 
      metalloprotease-9 (MMP-9) induction between the sciatic nerve and optic nerve 
      after crush injury in the same animal. In sciatic nerve, BNB disruption, 
      fibrin(ogen) deposition and MMP-9 expression were observed only in the first week 
      following injury. Neurofilament (NF) immunoreactivity dramatically decreased in 
      the first 2 days, gradually recovered to the normal levels by day 28. In 
      contrast, the immunoglobulin G deposits spanned from 4 h to 28 days in crushed 
      optic nerves. Fibrin(ogen) deposition was only observed in the first 2 days, 
      while MMP-9 induction did not occur until a week after injury but lasted for 3 
      weeks in the crushed optic nerves. The NF immunoreactivity did not change much 
      until day 7 and almost completely disappeared on day 28. The decrease of NF 
      immunoreactivity coincided with the induction of MMP-9 after optic nerve crush. 
      These results show that BNB disruption and MMP-9 induction are differentially 
      regulated in the PNS and CNS after injuries, and they may contribute to the 
      different regeneration capacities of the two systems.
FAU - Liu, Li-Yun
AU  - Liu LY
AD  - Department of Anatomy, Histology and Embryology, Shanghai Medical School, Fudan 
      University, 200032 Shanghai, China.
FAU - Zheng, Hua
AU  - Zheng H
FAU - Xiao, Hong-Lei
AU  - Xiao HL
FAU - She, Zhen-Jue
AU  - She ZJ
FAU - Zhao, Shu-Min
AU  - Zhao SM
FAU - Chen, Zu-Lin
AU  - Chen ZL
FAU - Zhou, Guo-Min
AU  - Zhou GM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080103
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Immunoglobulin G)
RN  - 0 (Neurofilament Proteins)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, mouse)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*enzymology/pathology
MH  - Extracellular Matrix/enzymology
MH  - Immunoglobulin G/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Crush
MH  - Neurofilament Proteins/metabolism
MH  - Optic Nerve/*enzymology/pathology
MH  - Optic Nerve Injuries/*metabolism/pathology
MH  - Sciatic Nerve/*enzymology/*injuries/pathology
EDAT- 2008/02/05 09:00
MHDA- 2008/06/19 09:00
CRDT- 2008/02/05 09:00
PHST- 2007/08/28 00:00 [received]
PHST- 2007/11/06 00:00 [revised]
PHST- 2007/12/19 00:00 [accepted]
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/06/19 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0304-3940(07)01324-9 [pii]
AID - 10.1016/j.neulet.2007.12.052 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Mar 28;434(2):155-9. doi: 10.1016/j.neulet.2007.12.052. Epub 
      2008 Jan 3.