PMID- 18243629
OWN - NLM
STAT- MEDLINE
DCOM- 20080630
LR  - 20200106
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 26
IP  - 3-4
DP  - 2008 May-Jun
TI  - Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in 
      vitro requires activation of extracellular signal-regulated kinase and 
      phosphatidylinositol 3-kinase.
PG  - 363-70
LID - 10.1016/j.ijdevneu.2007.11.005 [doi]
AB  - Intrauterine asphyxia is one of the major contributors for perinatal death, 
      mental and physical disorders of surviving children. Brain-derived neurotrophic 
      factor (BDNF) provides a promising solution to hypoxic injury due to its 
      survival-promoting effects. In an attempt to identify possible molecular 
      mechanisms underlying the neuroprotective role of BDNF, we studied extracellular 
      signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI-3-K) and p38 
      mitogen-activated protein kinase (MAPK) pathways. We demonstrated that BDNF 
      protected cortical neurons against hypoxic injury in vitro via activation of both 
      the ERK and PI-3-K pathways but not the p38 MAPK pathway. We also showed that 
      both hypoxic stimuli and exogenous BDNF treatment phosphorylated the cyclic AMP 
      response element-binding protein (CREB) and that CREB phosphorylation induced by 
      BDNF was mediated via the ERK pathway in cultured cortical neurons.
FAU - Sun, Xiaomei
AU  - Sun X
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu, PR China.
FAU - Zhou, Hui
AU  - Zhou H
FAU - Luo, Xiaoli
AU  - Luo X
FAU - Li, Shengfu
AU  - Li S
FAU - Yu, Dan
AU  - Yu D
FAU - Hua, Jiping
AU  - Hua J
FAU - Mu, Dezhi
AU  - Mu D
FAU - Mao, Meng
AU  - Mao M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071217
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Neuroprotective Agents)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Animals
MH  - Brain/*enzymology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cells, Cultured
MH  - Cerebral Cortex/drug effects/enzymology/physiopathology
MH  - Cyclic AMP Response Element-Binding Protein/drug effects/metabolism
MH  - Enzyme Activation/drug effects
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - Fetal Hypoxia/*enzymology/physiopathology
MH  - Hypoxia-Ischemia, Brain/drug therapy/*enzymology/physiopathology
MH  - Mitogen-Activated Protein Kinase 3/*metabolism
MH  - Neurons/drug effects/enzymology
MH  - Neuroprotective Agents/pharmacology
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Phosphorylation/drug effects
MH  - Pregnancy
MH  - Rats
EDAT- 2008/02/05 09:00
MHDA- 2008/07/01 09:00
CRDT- 2008/02/05 09:00
PHST- 2007/09/19 00:00 [received]
PHST- 2007/11/16 00:00 [revised]
PHST- 2007/11/29 00:00 [accepted]
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/07/01 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0736-5748(07)00177-3 [pii]
AID - 10.1016/j.ijdevneu.2007.11.005 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2008 May-Jun;26(3-4):363-70. doi: 
      10.1016/j.ijdevneu.2007.11.005. Epub 2007 Dec 17.