PMID- 1824515
OWN - NLM
STAT- MEDLINE
DCOM- 19921022
LR  - 20161026
IS  - 0004-0622 (Print)
IS  - 0004-0622 (Linking)
VI  - 41
IP  - 3
DP  - 1991 Sep
TI  - [Hematologic changes in rats treated with high doses of vitamin K3 (menadione)].
PG  - 363-74
AB  - The present study describes the effect of high doses of vitamin K3 (8-30 mg/kg) 
      administered daily by intramuscular injection during seven days; on blood smear, 
      red blood cells (RBC) and concentration of hemoglobin (Hb) counts, value of 
      hematocrit (Ht), mean corpuscular hemoglobin concentration (MCHC), reticulocyte 
      and erythroblast counts, total and differential counting of leukocytes (WBC) and 
      total and fractionated serum bilirubin concentration of albino male rats. Results 
      were then compared with findings in normal rats treated with the same doses of 
      sodium bisulfite. In animals treated with vitamin K3 a statistically significant 
      decrease in the number of erythrocytes and in the concentration of Hb, Ht and 
      MCHC was found together with a concomitant increase of erythroblast and 
      reticulocyte counting. In regard to the blood smear, it was observed that 
      erythrocytes vary in their hemoglobin content, size, shape and in their staining 
      properties (polychromatophilia) where as the leukocytes were found to be 
      morphologically normal, but in an increased number. Lymphocytes occasionally 
      showed azurophil granules. Platelets assumed irregular shape and in normal 
      amounts. The leukocytes count showed leukocytosis with marked neutrophilia, 
      eosinophilia, lymphocytosis and monocytosis. Also, the presence of clinical 
      jaundice with an increase of the serum "indirectly-reacting" bilirubin was also 
      observed. These findings indicate that hypervitaminosis K3 induces a marked 
      hemolytic microcytic hypochromic anemia and changes in the white blood cells 
      count. Further studies will be pursued in order to obtain a better understanding 
      of the causes and/or the mechanisms that induce these alterations in the blood 
      cells.
FAU - Alarcon, O M
AU  - Alarcon OM
AD  - Universidad de Los Andes, Merida, Venezuela.
FAU - Vasquez, F
AU  - Vasquez F
FAU - Acosta, A
AU  - Acosta A
FAU - Burguera, J L
AU  - Burguera JL
FAU - Burguera, M
AU  - Burguera M
FAU - Ortega, S Y
AU  - Ortega SY
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Alteraciones hematologicas en ratas tratadas con dosis elevadas de vitamina K3 
      (menadiona).
PL  - Venezuela
TA  - Arch Latinoam Nutr
JT  - Archivos latinoamericanos de nutricion
JID - 0067507
RN  - 0 (Hemoglobins)
RN  - 12001-79-5 (Vitamin K)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Analysis of Variance
MH  - Anemia, Hemolytic/blood/*chemically induced/epidemiology
MH  - Animals
MH  - Bilirubin/blood
MH  - Body Weight
MH  - Epidemiologic Methods
MH  - Erythrocyte Indices
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Injections, Intramuscular
MH  - Leukocyte Count
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Venezuela/epidemiology
MH  - Vitamin K/administration & dosage/*adverse effects
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
PST - ppublish
SO  - Arch Latinoam Nutr. 1991 Sep;41(3):363-74.