PMID- 18245686
OWN - NLM
STAT- MEDLINE
DCOM- 20080328
LR  - 20220408
IS  - 0002-8177 (Print)
IS  - 0002-8177 (Linking)
VI  - 139
IP  - 2
DP  - 2008 Feb
TI  - Adverse events associated with chlorhexidine use: results from the Department of 
      Veterans Affairs Dental Diabetes Study.
PG  - 178-83
AB  - BACKGROUND: The authors report adverse events (AEs) related to the use of 
      chlorhexidine gluconate mouthrinse in a clinical trial of the efficacy of 
      periodontal treatment in older adults with diabetes. METHODS: Participants were 
      U.S. veterans with uncontrolled diabetes (hemoglobin A(1c) value > or =8.5 
      percent) and periodontal disease. Treatment included periodontal scaling, 0.12 
      percent chlorhexidine lavage during ultrasonic scaling and use of chlorhexidine 
      mouthrinse at home. RESULTS: Forty-four (31 percent) of 140 subjects reported 
      having AEs. Most common were taste changes and tooth staining, sore mouth and/or 
      throat, tongue irritation and wheezing/shortness of breath; the latter was 
      reported more commonly before chlorhexidine use than after. Only body mass index 
      greater than 30 was significantly related to AEs. CONCLUSIONS: AEs are common 
      among subjects using chlorhexidine mouthrinse. Most AEs (taste change and 
      staining) were resolved easily by subjects' discontinuing mouthrinse use and 
      receiving dental prophylaxis. No serious AEs were reported. CLINICAL 
      IMPLICATIONS: Clinicians should advise patients using chlorhexidine mouthrinse of 
      possible side effects. If necessary, patients should discontinue mouthrinse use 
      and obtain medical care. Careful monitoring of AEs in patients using 
      chlorhexidine is warranted.
FAU - McCoy, Linda C
AU  - McCoy LC
AD  - Center for Health Quality, Outcomes and Economic Research, Edith Nourse Rogers 
      Memorial Veterans Hospital, 200 Springs Road (152), Bedford, MA 01730, USA. 
      mccoyl@bu.edu
FAU - Wehler, Carolyn J
AU  - Wehler CJ
FAU - Rich, Sharron E
AU  - Rich SE
FAU - Garcia, Raul I
AU  - Garcia RI
FAU - Miller, Donald R
AU  - Miller DR
FAU - Jones, Judith A
AU  - Jones JA
LA  - eng
GR  - K24 DE 00419/DE/NIDCR NIH HHS/United States
GR  - K24 DE 018211/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Mouthwashes)
RN  - R4KO0DY52L (Chlorhexidine)
SB  - IM
MH  - Anti-Infective Agents, Local/*adverse effects
MH  - Body Mass Index
MH  - Chlorhexidine/*adverse effects
MH  - Dental Scaling
MH  - *Diabetes Complications
MH  - Female
MH  - Follow-Up Studies
MH  - Glossitis/chemically induced
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouthwashes/*adverse effects
MH  - Periodontal Diseases/*prevention & control
MH  - Pharyngitis/chemically induced
MH  - Respiratory Sounds/etiology
MH  - Self Care
MH  - Single-Blind Method
MH  - Stomatitis/chemically induced
MH  - Taste Disorders/chemically induced
MH  - Therapeutic Irrigation
MH  - Tooth Discoloration/chemically induced
MH  - Ultrasonic Therapy
EDAT- 2008/02/05 09:00
MHDA- 2008/03/29 09:00
CRDT- 2008/02/05 09:00
PHST- 2008/02/05 09:00 [pubmed]
PHST- 2008/03/29 09:00 [medline]
PHST- 2008/02/05 09:00 [entrez]
AID - S0002-8177(14)60684-X [pii]
AID - 10.14219/jada.archive.2008.0134 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2008 Feb;139(2):178-83. doi: 10.14219/jada.archive.2008.0134.