PMID- 18248305
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20211020
IS  - 0022-1899 (Print)
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 197
IP  - 3
DP  - 2008 Feb 1
TI  - Association between Cryptosporidium infection and human leukocyte antigen class I 
      and class II alleles.
PG  - 474-8
LID - 10.1086/525284 [doi]
AB  - BACKGROUND: Cryptosporidium species are a common cause of diarrhea, which can be 
      severe and protracted in young children and immunocompromised individuals. 
      METHODS: A cohort of 226 Bangladeshi children aged 2-5 years was prospectively 
      followed for >3 years to study the role of host genetics in susceptibility to 
      infection, as well as the community impact of cryptosporidiosis on this 
      population. RESULTS: Ninety-six children (42.5%) received a diagnosis of 
      Cryptosporidium infection. A total of 51 (22.6%) had asymptomatic infection. 
      Fifty-eight (25.7%) had cryptosporidiosis, of whom 17 (29.3%) had recurrent 
      disease. Children with cryptosporidiosis presented early, and most had abdominal 
      pain and a short course of diarrhea. Infected children were more likely to carry 
      the human leukocyte antigen (HLA) class II DQB1*0301 allele, particularly those 
      with both asymptomatic and symptomatic infection (P = .009); a strong association 
      was found between carriage of the DQB1*0301/DRB1*1101 haplotype and development 
      of both asymptomatic and symptomatic infection (P = .009). Infected children were 
      also more likely to carry the B*15 HLA class I allele. CONCLUSIONS: This is the 
      first study to describe a possible genetic component of the immune response to 
      Cryptosporidium infection, which includes HLA class I and II alleles. 
      Cryptosporidiosis in Bangladeshi children aged 2-5 year is common and often 
      recurrent, but the duration is shorter and the abdominal pain greater than that 
      described in children aged <2 years.
FAU - Kirkpatrick, Beth D
AU  - Kirkpatrick BD
AD  - University of Vermont College of Medicine, Unit of Infectious Diseases, 
      Burlington, VT 05405, USA. beth.kirkpatrick@uvm.edu
FAU - Haque, Rashidul
AU  - Haque R
FAU - Duggal, Priya
AU  - Duggal P
FAU - Mondal, Dinesh
AU  - Mondal D
FAU - Larsson, Cathy
AU  - Larsson C
FAU - Peterson, Kristine
AU  - Peterson K
FAU - Akter, Jasmin
AU  - Akter J
FAU - Lockhart, Lauren
AU  - Lockhart L
FAU - Khan, Salwa
AU  - Khan S
FAU - Petri, William A Jr
AU  - Petri WA Jr
LA  - eng
GR  - R01 AI043596/AI/NIAID NIH HHS/United States
GR  - AI0143596/AI/NIAID NIH HHS/United States
GR  - U54 AI57168/AI/NIAID NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - U54 AI057168/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-D Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Animals
MH  - Bangladesh/epidemiology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cryptosporidiosis/epidemiology/*immunology
MH  - Cryptosporidium/*immunology/isolation & purification
MH  - Feces/parasitology
MH  - HLA-D Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Recurrence
MH  - Reference Values
PMC - PMC3404124
MID - NIHMS391769
COIS- Potential conflicts of interest: none reported.
EDAT- 2008/02/06 09:00
MHDA- 2008/04/02 09:00
PMCR- 2012/07/24
CRDT- 2008/02/06 09:00
PHST- 2008/02/06 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2008/02/06 09:00 [entrez]
PHST- 2012/07/24 00:00 [pmc-release]
AID - 10.1086/525284 [doi]
PST - ppublish
SO  - J Infect Dis. 2008 Feb 1;197(3):474-8. doi: 10.1086/525284.