PMID- 18249304
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20090520
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 19
IP  - 2
DP  - 2008 Mar
TI  - Multiple Endocrine Neoplasia type 1.
PG  - 99-103
LID - 10.1016/j.ejim.2007.08.004 [doi]
AB  - The co-occurrence of parathyroid hyperplasia with pancreatic endocrine tumours 
      and/or pituitary adenoma is classified as Multiple Endocrine Neoplasia type 1 
      (MEN-1) and is caused by a germ-line mutation in MEN-1 gene encoding a tumour 
      suppressor protein, menin. This review presents clinical expressions, diagnosis 
      and management of the MEN-1 syndrome. Properties and mechanisms of menin 
      functions are also reviewed.
FAU - Piecha, Grzegorz
AU  - Piecha G
AD  - Department of Nephrology, Endocrinology and Metabolic Diseases, Medical 
      University of Silesia, Katowice, ul. Francuska 20/24, 40-027 Katowice, Poland.
FAU - Chudek, Jerzy
AU  - Chudek J
FAU - Wiecek, Andrzej
AU  - Wiecek A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20071107
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Gastrinoma/diagnosis/genetics
MH  - Gene Expression
MH  - Humans
MH  - Hyperparathyroidism/diagnosis/genetics
MH  - Insulinoma/diagnosis/genetics
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics/therapy
MH  - Mutation
MH  - Prolactinoma/diagnosis/genetics
MH  - Proto-Oncogene Proteins/genetics/*physiology
RF  - 63
EDAT- 2008/02/06 09:00
MHDA- 2008/06/18 09:00
CRDT- 2008/02/06 09:00
PHST- 2007/03/10 00:00 [received]
PHST- 2007/07/06 00:00 [revised]
PHST- 2007/08/30 00:00 [accepted]
PHST- 2008/02/06 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2008/02/06 09:00 [entrez]
AID - S0953-6205(07)00262-2 [pii]
AID - 10.1016/j.ejim.2007.08.004 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2008 Mar;19(2):99-103. doi: 10.1016/j.ejim.2007.08.004. Epub 
      2007 Nov 7.