PMID- 18250121
OWN - NLM
STAT- MEDLINE
DCOM- 20080612
LR  - 20191210
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Linking)
VI  - 81
IP  - 965
DP  - 2008 May
TI  - Superiority of intensity-modulated radiotherapy over three-dimensional conformal 
      radiotherapy combined with brachytherapy in nasopharyngeal carcinoma: a planning 
      study.
PG  - 397-405
LID - 10.1259/bjr/36110151 [doi]
AB  - A planning study was performed in order to investigate the potential benefits of 
      intensity-modulated radiotherapy using a simultaneous integrated multi-target 
      treatment technique (SIMT-IMRT) over highly optimized three-dimensional conformal 
      radiotherapy combined with intracavitary brachytherapy (3D-CRT + IBT) for the 
      treatment of nasopharyngeal carcinoma (NPC). The subjects were eight patients 
      with Stages I-IV NPC. For each case, two sets of plans were prepared after 
      delineation of gross tumour volumes, three planning target volumes (PTVs) and 17 
      organs at risk (OARs). Dose prescriptions for PTVs were 72.6 Gy, 66 Gy and 52.8 
      Gy in 33 fractions for SIMT-IMRT vs 72 Gy (66 Gy in 33 fractions for 3D-CRT and 3 
      Gy twice for IBT), 66 Gy (in 33 fractions) and 46 Gy (in 23 fractions) for 3D-CRT 
      + IBT plans. Compared with the combined plans, SIMT-IMRT provided superior 
      results for the primary tumour (PT) in terms of mean equivalent uniform dose (67 
      Gy vs 63.7 Gy, p = 0.016). IMRT plans increased the mean tumour control 
      probability (TCP) values (both uncorrected and corrected for accelerated tumour 
      repopulation after 28 days) for PT when compared with 3D-CRT + IBT (98% and 94.3% 
      vs 95.8% and 89.9%, respectively, p = 0.016). Mean doses to middle/external ears, 
      parotid glands and temporomandibular joints were significantly lower in IMRT 
      plans. Our conclusion is that, for all stages of NPC, SIMT-IMRT was superior to 
      highly optimized 3D-CRT + IBT in terms of tumour coverage, increased local TCP, 
      and dose reduction to some OARs. We recommend that SIMT-IMRT should be considered 
      as a first-line radiotherapy technique for NPC.
FAU - Taheri-Kadkhoda, Z
AU  - Taheri-Kadkhoda Z
AD  - Department of Oncology, Sahlgrenska University Hospital, SE 413 45 Goteborg, 
      Sweden. zahra.taheri-kadkhoda@vgregion.se
FAU - Pettersson, N
AU  - Pettersson N
FAU - Bjork-Eriksson, T
AU  - Bjork-Eriksson T
FAU - Johansson, K-A
AU  - Johansson KA
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20080204
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Brachytherapy/*methods
MH  - Humans
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Conformal/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Treatment Outcome
EDAT- 2008/02/06 09:00
MHDA- 2008/06/13 09:00
CRDT- 2008/02/06 09:00
PHST- 2008/02/06 09:00 [pubmed]
PHST- 2008/06/13 09:00 [medline]
PHST- 2008/02/06 09:00 [entrez]
AID - 36110151 [pii]
AID - 10.1259/bjr/36110151 [doi]
PST - ppublish
SO  - Br J Radiol. 2008 May;81(965):397-405. doi: 10.1259/bjr/36110151. Epub 2008 Feb 
      4.