PMID- 18250135
OWN - NLM
STAT- MEDLINE
DCOM- 20080507
LR  - 20221207
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 17
IP  - 2
DP  - 2008 Feb
TI  - A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic 
      lupus erythematosus patients.
PG  - 124-7
LID - 10.1177/0961203307086031 [doi]
AB  - Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune 
      diseases and various cancers and infectious diseases. An IL-18 genetic A/C 
      polymorphism at coding position 105 (rs549908) has been linked with asthma and 
      rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism 
      confers systemic lupus erythematosus (SLE) susceptibility. Study participants 
      were Taiwanese SLE patients and a healthy control group. Our results indicate (1) 
      a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 
      95% CI = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE 
      patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 
      0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE 
      pathogenesis.
FAU - Lin, Y-J
AU  - Lin YJ
AD  - Department of Medical Research, China Medical University Hospital, Taichung, 
      Taiwan.
FAU - Wan, L
AU  - Wan L
FAU - Sheu, J J-C
AU  - Sheu JJ
FAU - Huang, C-M
AU  - Huang CM
FAU - Lin, C-W
AU  - Lin CW
FAU - Lan, Y-C
AU  - Lan YC
FAU - Lai, C-H
AU  - Lai CH
FAU - Hung, C-H
AU  - Hung CH
FAU - Tsai, Y
AU  - Tsai Y
FAU - Tsai, C-H
AU  - Tsai CH
FAU - Lin, T-H
AU  - Lin TH
FAU - Chen, C-P
AU  - Chen CP
FAU - Tsai, F-J
AU  - Tsai FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Lupus Erythematosus, Systemic/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Severity of Illness Index
MH  - Taiwan
EDAT- 2008/02/06 09:00
MHDA- 2008/05/08 09:00
CRDT- 2008/02/06 09:00
PHST- 2008/02/06 09:00 [pubmed]
PHST- 2008/05/08 09:00 [medline]
PHST- 2008/02/06 09:00 [entrez]
AID - 17/2/124 [pii]
AID - 10.1177/0961203307086031 [doi]
PST - ppublish
SO  - Lupus. 2008 Feb;17(2):124-7. doi: 10.1177/0961203307086031.