PMID- 18253967
OWN - NLM
STAT- MEDLINE
DCOM- 20080701
LR  - 20080218
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Linking)
VI  - 507
IP  - 5
DP  - 2008 Apr 10
TI  - Ontogeny of altered dendritic morphology in the rat prefrontal cortex, 
      hippocampus, and nucleus accumbens following Cesarean delivery and birth anoxia.
PG  - 1734-47
LID - 10.1002/cne.21651 [doi]
AB  - We used a delayed Cesarean birth model and the Golgi-Cox staining method to 
      investigate the effects of perinatal anoxia on prefrontal cortex (PFC) and 
      hippocampal (CA1) pyramidal neurons as well as nucleus accumbens (NAcc) medium 
      spiny neurons. Dendritic morphology in these regions was studied on postnatal 
      days (P) 2, 7, 14, 21, 35, and 70 in male Sprague-Dawley rats born either 
      vaginally (VAG) or by Cesarean section either with (C + anoxia) or without 
      (C-only) anoxia. The most striking birth group differences seen were at the level 
      of dendritic spine densities on P35. During this postnatal period the dendritic 
      spine density of PFC neurons was significantly lower in C + anoxia and C-only 
      animals than in VAG controls; however, by P70 PFC spine densities in all birth 
      groups were comparable. In contrast, hippocampal spine densities on P35 were 
      comparably greater in C + anoxia animals than in VAG controls, whereas in C-only 
      animals spine densities were lower than controls; here again, by P70 all groups 
      had comparable hippocampal spine densities. In NAcc greater spine densities were 
      seen on medium spiny neurons of C + anoxia animals on P35. These findings provide 
      evidence that perinatal insult in the form of Cesarean birth with or without 
      anoxia alters the dendritic development of PFC and hippocampal pyramidal neurons 
      and to some extent also of NAcc medium spiny neurons. They also suggest that 
      perinatal anoxia can alter the neuronal development of key structures thought to 
      be affected in such late-onset dopamine-related disorders as schizophrenia and 
      Attention Deficit Hyperactivity Disorder (ADHD).
CI  - (c) 2008 Wiley-Liss, Inc.
FAU - Juarez, Ismael
AU  - Juarez I
AD  - Laboratorio de Neuropsiquiatria, Instituto de Fisiologia, Universidad Autonoma de 
      Puebla, Puebla 72570, Mexico.
FAU - Gratton, Alan
AU  - Gratton A
FAU - Flores, Gonzalo
AU  - Flores G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Birth Injuries/*ultrastructure
MH  - Brain/*ultrastructure
MH  - Cesarean Section/*adverse effects
MH  - Dendrites/*ultrastructure
MH  - Female
MH  - Fetal Hypoxia/ultrastructure
MH  - Hypoxia, Brain/*pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2008/02/07 09:00
MHDA- 2008/07/02 09:00
CRDT- 2008/02/07 09:00
PHST- 2008/02/07 09:00 [pubmed]
PHST- 2008/07/02 09:00 [medline]
PHST- 2008/02/07 09:00 [entrez]
AID - 10.1002/cne.21651 [doi]
PST - ppublish
SO  - J Comp Neurol. 2008 Apr 10;507(5):1734-47. doi: 10.1002/cne.21651.