PMID- 18254909
OWN - NLM
STAT- MEDLINE
DCOM- 20080513
LR  - 20211020
IS  - 0803-5253 (Print)
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 97
IP  - 2
DP  - 2008 Feb
TI  - Adverse reactions to milk in infants.
PG  - 196-200
LID - 10.1111/j.1651-2227.2007.00599.x [doi]
AB  - AIM: To study the age when symptoms of adverse reactions to milk occur, in 
      premature and term children, the debut of various symptoms, immunoglobulin E 
      (IgE)- and non-IgE-mediated reactions and the frequency of tolerance at 1 year. 
      METHODS: Six hundred and eight children, 193 premature and 416 term infants, were 
      followed. Symptomatic children were invited to a clinical examination. The 
      criteria for the diagnosis were: histories of suspected cow's milk allergy (CMA) 
      and proven IgE-mediated reactions to cow's milk or positive elimination/challenge 
      tests. RESULTS: Twenty-seven out of 555 (4.9%) were diagnosed with adverse 
      reactions to cow's milk. All had symptoms before 6 months of age. The main 
      symptoms were: pain behaviour (13), gastrointestinal symptoms (7), respiratory 
      symptoms, (6) and atopic dermatitis (1). One child had proven IgE to cow's milk. 
      Premature and term infants displayed the same symptoms and age of debut. Thirteen 
      children were tolerant to cow's milk at 1 year. CONCLUSION: Adverse reactions to 
      milk start early in life, with pain behaviour, gastrointestinal, and respiratory 
      symptoms being the most common, and rarely atopic dermatitis. Non-IgE-mediated 
      reactions were the most frequent. Symptoms and age of debut were the same in 
      premature and term infants. Half of the children tolerated cow's milk at age 1.
FAU - Kvenshagen, Bente
AU  - Kvenshagen B
AD  - Oestfold Hospital Trust, Department of Pediatrics, Fredrikstad, Norway. 
      bent-kv@online.no
FAU - Halvorsen, Ragnhild
AU  - Halvorsen R
FAU - Jacobsen, Morten
AU  - Jacobsen M
LA  - eng
PT  - Journal Article
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Dermatitis, Atopic/etiology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Milk Hypersensitivity/diagnosis/*epidemiology
MH  - Skin Tests
MH  - Surveys and Questionnaires
PMC - PMC2253707
EDAT- 2008/02/08 09:00
MHDA- 2008/05/14 09:00
PMCR- 2008/02/25
CRDT- 2008/02/08 09:00
PHST- 2008/02/08 09:00 [pubmed]
PHST- 2008/05/14 09:00 [medline]
PHST- 2008/02/08 09:00 [entrez]
PHST- 2008/02/25 00:00 [pmc-release]
AID - APA599 [pii]
AID - 10.1111/j.1651-2227.2007.00599.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2008 Feb;97(2):196-200. doi: 10.1111/j.1651-2227.2007.00599.x.