PMID- 1825644
OWN - NLM
STAT- MEDLINE
DCOM- 19910409
LR  - 20190828
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 29
IP  - 1
DP  - 1991 Jan
TI  - Chronic inhalation toxicity and carcinogenicity study of methyl bromide in Wistar 
      rats.
PG  - 31-9
AB  - The toxicity and carcinogenicity of methyl bromide (MeBr) were studied in male 
      and female Wistar rats exposed by inhalation to 0, 3, 30 or 90 ppm MeBr 6hr/day, 
      5 days/wk for 29 months. After 13, 52 and 104 wk ten rats/sex/group were killed 
      to provide interim information. Body weights, clinical signs, haematology, 
      biochemistry and gross and microscopic pathology were studied. Mortality was 
      increased by wk 114 in the 90-ppm group. Body weights in males and females of the 
      90-ppm group were lower than those of the controls throughout the study. 
      Increased incidences of degenerative and hyperplastic changes of the nasal 
      olfactory epithelium were observed in all exposed groups, the incidences being 
      positively correlated with the MeBr concentration; the nasal lesions did not 
      progress appreciably with time. Exposure to 90 ppm MeBr was associated with an 
      increased incidence of lesions in the heart (thrombi, myocardial degeneration), 
      and with hyperkeratosis in the oesophagus and forestomach. Data on site, type and 
      incidence of tumours in the various groups did not indicate carcinogenic activity 
      of MeBr.
FAU - Reuzel, P G
AU  - Reuzel PG
AD  - TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
FAU - Dreef-van der Meulen, H C
AU  - Dreef-van der Meulen HC
FAU - Hollanders, V M
AU  - Hollanders VM
FAU - Kuper, C F
AU  - Kuper CF
FAU - Feron, V J
AU  - Feron VJ
FAU - van der Heijden, C A
AU  - van der Heijden CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Hydrocarbons, Brominated)
RN  - 9V42E1Z7B6 (methyl bromide)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Blood Urea Nitrogen
MH  - Body Weight/drug effects
MH  - Brain/drug effects
MH  - Female
MH  - Heart/drug effects
MH  - Hydrocarbons, Brominated/administration & dosage/*toxicity
MH  - Hyperplasia
MH  - Kidney/drug effects
MH  - Male
MH  - Nasal Mucosa/drug effects
MH  - Neoplasms, Experimental/*chemically induced
MH  - Organ Size/drug effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Specific Pathogen-Free Organisms
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0278-6915(91)90060-K [pii]
AID - 10.1016/0278-6915(91)90060-k [doi]
PST - ppublish
SO  - Food Chem Toxicol. 1991 Jan;29(1):31-9. doi: 10.1016/0278-6915(91)90060-k.