PMID- 1825647
OWN - NLM
STAT- MEDLINE
DCOM- 19910410
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 17
IP  - 3
DP  - 1991 Mar
TI  - Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats.
PG  - 308-16
AB  - The purpose of this study was to examine effects of antihypertensive treatment on 
      structure and mechanics of cerebral arterioles and the incidence of stroke in 
      stroke-prone spontaneously hypertensive rats (SHRSP). Treatment of hypertension 
      was begun at 3 months of age with cilazapril (45 mg/kg/day), an angiotensin 
      converting enzyme (ACE) inhibitor, or with hydralazine (18 mg/kg/day). Cilazapril 
      and hydralazine reduced systolic arterial pressure (from 195 +/- 8 to 125 +/- 5 
      and 148 +/- 3 mm Hg, respectively [mean +/- SEM]; p less than 0.05). To examine 
      structure and mechanics of cerebral arterioles, we measured pressure (servonull), 
      external diameter, and cross-sectional area of the vessel wall (histologically) 
      in pial arterioles of normotensive Wistar-Kyoto (WKY) rats and SHRSP that were 
      untreated or that were treated for 3 months with cilazapril or with hydralazine. 
      Arterioles were maximally dilated with EDTA. In WKY rats, cilazapril and 
      hydralazine did not alter pial arteriolar pressure, external diameter, or 
      cross-sectional area of the vessel wall. In SHRSP, both cilazapril and 
      hydralazine reduced cross-sectional area of the vessel wall to levels not 
      significantly different from WKY rats (from 1,911 +/- 155 to 1,244 +/- 101 and 
      1,388 +/- 59 microns 2, respectively, compared with 1,405 +/- 95 microns 2 for 
      untreated WKY rats). Cilazapril was more effective than hydralazine in reducing 
      pial arteriolar pressure (from 110 +/- 6 to 62 +/- 2 mm Hg with cilazapril versus 
      79 +/- 5 mm Hg for hydralazine compared with 60 +/- 4 mm Hg for untreated WKY 
      rats). Cilazapril, but not hydralazine, attenuated reductions in external 
      diameter of pial arterioles (from 91 +/- 4 to 100 +/- 4 microns for cilazapril 
      versus 91 +/- 3 microns for hydralazine compared with 107 +/- 3 microns for 
      untreated WKY rats).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Hajdu, M A
AU  - Hajdu MA
AD  - University of Iowa College of Medicine, Department of Pathology, Iowa City 52242.
FAU - Heistad, D D
AU  - Heistad DD
FAU - Baumbach, G L
AU  - Baumbach GL
LA  - eng
GR  - HL-16066/HL/NHLBI NIH HHS/United States
GR  - HL-22149/HL/NHLBI NIH HHS/United States
GR  - NS-24621/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Pyridazines)
RN  - 19KW7PI29F (Cilazapril)
RN  - 26NAK24LS8 (Hydralazine)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/*pharmacology
MH  - Animals
MH  - Arterioles/drug effects/physiology
MH  - Blood Pressure/drug effects
MH  - Cerebral Arteries/*drug effects/pathology/physiology
MH  - Cerebrovascular Disorders/prevention & control
MH  - Cilazapril
MH  - Hydralazine/*pharmacology
MH  - Hypertension/*drug therapy/pathology/physiopathology
MH  - Hypertrophy
MH  - Male
MH  - Pyridazines/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 10.1161/01.hyp.17.3.308 [doi]
PST - ppublish
SO  - Hypertension. 1991 Mar;17(3):308-16. doi: 10.1161/01.hyp.17.3.308.