PMID- 18256983
OWN - NLM
STAT- MEDLINE
DCOM- 20080423
LR  - 20080207
IS  - 0271-8235 (Print)
IS  - 0271-8235 (Linking)
VI  - 28
IP  - 1
DP  - 2008 Feb
TI  - Genetics and natural history of multiple sclerosis.
PG  - 7-16
LID - 10.1055/s-2007-1019125 [doi]
AB  - Recent studies have better defined the association between the human leukocyte 
      antigen (HLA)-DR, cytotoxic T-lymphocyte antigen-4, interleukin-7 receptor, and 
      interferon-gamma polymorphisms and susceptibility to multiple sclerosis (MS), 
      while many more studies have been added to the controversial pool of likely 
      false-positive and false-negative genetic association and linkage studies. 
      Apolipoprotein E alleles may yet play an important role in disease course and 
      cognitive impairment, although largely refuted as being directly associated with 
      ambulatory measures of disease severity. Natural history studies have started to 
      better define the clinical phenotypic heterogeneity of idiopathic inflammatory 
      diseases of the central nervous system, fueling new hypotheses about 
      immunopathogenesis of MS. Our understanding of phenotype measurement tools is 
      improving. However, despite all the ongoing effort, the cause of MS and the 
      determinants of heterogeneity in the clinical phenotype of MS remain largely 
      unknown. As advances in our understanding of the immunobiology of MS start to 
      bridge the gap between pathological and clinical natural history of the disease, 
      biologically relevant phenotypes of MS will hopefully emerge to allow more 
      specific treatment modalities to be developed and brought to practice.
FAU - Kantarci, Orhun H
AU  - Kantarci OH
AD  - Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 
      55902, USA. kantarci.orhun@mayo.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Neurol
JT  - Seminars in neurology
JID - 8111343
SB  - IM
MH  - Demyelinating Diseases/epidemiology/pathology
MH  - Disease Progression
MH  - Humans
MH  - Multiple Sclerosis/epidemiology/*genetics/*pathology
MH  - Survival
MH  - Treatment Outcome
RF  - 102
EDAT- 2008/02/08 09:00
MHDA- 2008/04/24 09:00
CRDT- 2008/02/08 09:00
PHST- 2008/02/08 09:00 [pubmed]
PHST- 2008/04/24 09:00 [medline]
PHST- 2008/02/08 09:00 [entrez]
AID - 10.1055/s-2007-1019125 [doi]
PST - ppublish
SO  - Semin Neurol. 2008 Feb;28(1):7-16. doi: 10.1055/s-2007-1019125.