PMID- 18257268
OWN - NLM
STAT- MEDLINE
DCOM- 20090226
LR  - 20201209
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 32
IP  - 22
DP  - 2007 Nov
TI  - [Effects of Huoxiang Zhengqi liquid on enteric mucosal immune responses in mice 
      with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea].
PG  - 2397-400
AB  - OBJECTIVE: To explore the effects of Huoxiang Zhengqi liquid (HXZQ) on enteric 
      mucosal immune responses in mice with Bacillus dysenteriae and Salmonella 
      typhimurium induced diarrhea (BSD). METHOD: Mice were randomly divided into four 
      groups with 10 mice in each group: control group (control), BSD group, Huoxiang 
      Zhengqi liquid treated BSD groups at high dosage and low dosage (HXZQ high, HXZQ 
      low). HXZQ was administrated from the day of diarrhea induction at dosage of 5.21 
      g kg(-1) and 0.52 g kg (-1) respectively. Peyer's patch and periphery lymphocytes 
      were prepared for flow cytometry, and level of TNF-alpha in periphery and enteric 
      tissue homogenate were determined with ELISA. Student's t-test was used for 
      statistics. RESULT: Mice in BSD group started showing continuous diarrhea at the 
      day of induction till the fourth day when the mice were sacrificed. Diarrhea in 
      the mice of HXZQ high and low groups lasted for 36 and 54 h respectively. There 
      were more CD4+ and CD8+ cells in periphery, less CD4+ cells in peyer's patch in 
      BSD mice comparing to normal mice. In peyer's patch, there were more CD8+ cells 
      in mice in HXZQ high and low groups and more CD4+ in mice in HXZQ high group. 
      Higher level TNF-alpha in periphery and intestinal tissue homogenate in BSD group 
      were observed. Mice in HXZQ high group showed the decreased level TNF-alpha in 
      periphery and enteric tissue homogenate. CONCLUSION: The immune regulation on 
      peyer's patch CD4+ and CD8+ cells and suppression on TNF-alpha level in enteric 
      homogenate might partially explain the effect of HXZQ on improvement of BSD.
FAU - He, Ying-hui
AU  - He YH
AD  - National Pharmaceutical Engineering Center (NPEC) for Solid Preparation in 
      Chinese Herbal Medicine, Nanchang 330006, China.
FAU - Luo, Xiao-jian
AU  - Luo XJ
FAU - Qian, Xing-wen
AU  - Qian XW
FAU - Wu, Zhi-peng
AU  - Wu ZP
FAU - Lv, Ai-ping
AU  - Lv AP
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Huoxiang-zhengqi)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - CD4-CD8 Ratio
MH  - Colon/immunology/metabolism/pathology
MH  - Diarrhea/*immunology/metabolism/microbiology
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/administration & dosage/isolation & 
      purification/*pharmacology
MH  - Dysentery, Bacillary/immunology/metabolism/microbiology
MH  - Immunity, Mucosal/drug effects
MH  - Intestinal Mucosa/*immunology/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Peyer's Patches/drug effects/immunology/pathology
MH  - Plants, Medicinal/chemistry
MH  - Random Allocation
MH  - Salmonella Infections/immunology/metabolism/microbiology
MH  - Salmonella typhimurium/immunology
MH  - Shigella dysenteriae/immunology
MH  - T-Lymphocyte Subsets/drug effects/immunology/pathology
MH  - Tumor Necrosis Factor-alpha/blood/metabolism
EDAT- 2008/02/09 09:00
MHDA- 2009/02/27 09:00
CRDT- 2008/02/09 09:00
PHST- 2008/02/09 09:00 [pubmed]
PHST- 2009/02/27 09:00 [medline]
PHST- 2008/02/09 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(22):2397-400.