PMID- 18257750
OWN - NLM
STAT- MEDLINE
DCOM- 20080221
LR  - 20131121
IS  - 1474-8673 (Electronic)
IS  - 1474-8665 (Linking)
VI  - 28
IP  - 1
DP  - 2008 Jan
TI  - Peripheral administration of CDP-choline, phosphocholine or choline increases 
      plasma adrenaline and noradrenaline concentrations.
PG  - 41-58
LID - 10.1111/j.1474-8673.2007.00416.x [doi]
AB  - 1 Intraperitoneal (i.p.) injection of 200-600 mumol/kg of 
      cytidine-5'-diphosphocholine (CDP-choline) increased plasma adrenaline and 
      noradrenaline concentrations dose- and time-dependently. 2 CDP-choline treatment 
      caused several-fold increases in plasma concentrations of CDP-choline and its 
      metabolites phosphocholine, choline, cytidine monophosphate (CMP) and cytidine. 3 
      Equivalent doses (200-600 mumol/kg; i.p.) of phosphocholine or choline, but not 
      CMP or cytidine, increased plasma adrenaline and noradrenaline dose-dependently. 
      4 CDP-choline, phosphocholine and choline (600 mumol/kg; i.p.) augmented the 
      increases in plasma adrenaline and noradrenaline in response to graded 
      haemorrhage. 5 The increases in plasma adrenaline and noradrenaline induced by 
      i.p. 600 mumol/kg of CDP-choline, phosphocholine or choline were abolished by 
      pre-treatment with hexamethonium (15 mg/kg; i.p.), but not atropine (2 mg/kg; 
      i.p.). 6 At 320-32 000 mum concentrations, choline, but not CDP-choline or 
      phosphocholine, evoked catecholamine secretion from perfused adrenal gland. 
      Choline (3200 mum)-induced catecholamine secretion was attenuated by the presence 
      of 1 mum of hexamethonium or mecamylamine, but not atropine, in the perfusion 
      medium. 7 Intracerebroventricular (i.c.v.) injection of choline (0.5-1.5 mumol) 
      also increased plasma adrenaline and noradrenaline dose- and time-dependently. 
      Pre-treatment with mecamylamine (50 mug; i.c.v.) or hexamethonium (15 mg/kg; 
      i.p.), but not atropine (10 mug; i.c.v.), prevented i.c.v. choline (1.5 
      mumol)-induced elevations in plasma adrenaline and noradrenaline. 8 It is 
      concluded that i.p. administration of CDP-choline or its cholinergic metabolites 
      phosphocholine and choline increases plasma adrenaline and noradrenaline 
      concentrations by enhancing nicotinic cholinergic neurotransmission in the 
      sympatho-adrenal system. Central choline also activates the sympatho-adrenal 
      system by increasing central nicotinic cholinergic neurotransmission.
FAU - Cansev, M
AU  - Cansev M
AD  - Department of Pharmacology and Clinical Pharmacology, Uludag University Medical 
      School, Bursa 16059, Turkey.
FAU - Ilcol, Y O
AU  - Ilcol YO
FAU - Yilmaz, M S
AU  - Yilmaz MS
FAU - Hamurtekin, E
AU  - Hamurtekin E
FAU - Ulus, I H
AU  - Ulus IH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Auton Autacoid Pharmacol
JT  - Autonomic & autacoid pharmacology
JID - 101157306
RN  - 0 (Atropine Derivatives)
RN  - 0 (Nicotinic Antagonists)
RN  - 107-73-3 (Phosphorylcholine)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 536BQ2JVC7 (Cytidine Diphosphate Choline)
RN  - 5CSZ8459RP (Cytidine)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 80719I460H (methylatropine)
RN  - F469818O25 (Cytidine Monophosphate)
RN  - N91BDP6H0X (Choline)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenal Glands/innervation/metabolism
MH  - Animals
MH  - Atropine Derivatives/pharmacology
MH  - Autonomic Nervous System/drug effects/*metabolism/physiopathology
MH  - Central Nervous System/drug effects/*metabolism/physiopathology
MH  - Choline/administration & dosage/blood/*metabolism
MH  - Cytidine/metabolism
MH  - Cytidine Diphosphate Choline/administration & dosage/blood/*metabolism
MH  - Cytidine Monophosphate/metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Epinephrine/*blood
MH  - Female
MH  - Hemorrhage/blood/metabolism/physiopathology
MH  - Hexamethonium/pharmacology
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Mecamylamine/pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Norepinephrine/*blood
MH  - Phosphorylcholine/administration & dosage/blood/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2008/02/09 09:00
MHDA- 2008/02/22 09:00
CRDT- 2008/02/09 09:00
PHST- 2008/02/09 09:00 [pubmed]
PHST- 2008/02/22 09:00 [medline]
PHST- 2008/02/09 09:00 [entrez]
AID - AAP416 [pii]
AID - 10.1111/j.1474-8673.2007.00416.x [doi]
PST - ppublish
SO  - Auton Autacoid Pharmacol. 2008 Jan;28(1):41-58. doi: 
      10.1111/j.1474-8673.2007.00416.x.