PMID- 18257905
OWN - NLM
STAT- MEDLINE
DCOM- 20080422
LR  - 20101118
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 19
IP  - 2
DP  - 2008 Mar
TI  - Correlation between specific immunoglobulin E levels and the severity of 
      reactions in egg allergic patients.
PG  - 173-9
LID - 10.1111/j.1399-3038.2007.00602.x [doi]
AB  - Different studies proposed specific immunoglobulin E (IgE) cut-off levels for the 
      diagnosis of egg allergy. Little is known if IgE titres could be helpful for 
      prediction of the severity of the reaction. The aim of this study was to 
      determine whether IgE titres are associated with the severity of the reaction 
      during a standardized egg challenge. We reviewed data obtained during oral 
      challenge tests to egg performed between 2003 and 2005, and attributed a clinical 
      score to the positive reactions. Serum specific IgE levels were analysed in 
      relation with the severity of the reaction. We analysed data from 51 oral food 
      challenges to egg, raw or cooked. Sixteen challenges (31%) were negative and 35 
      (69%) were positive of which 13 challenges (37% of positive reactions) elicited a 
      severe reaction. IgE levels in our patients ranged from undetectable to 14.90 
      kU/l. We could determine a cut-off level of 8.20 kU/l for a 90% probability of 
      clinical reactivity. IgE titres were statistically significantly different 
      between the patients with absent, mild and moderate or severe reaction. Patients 
      with negative challenge had IgE levels between 0.35 and 6.41 kU/l (median 1.17), 
      those with mild and moderate reaction had IgE levels ranging from 0.35 to 14.90 
      (median 2.47) and patients with severe reactions had IgE between 1.18 and 11.00 
      (median 3.70) (p = 0.006). Our results show a correlation between IgE titres and 
      the severity of the clinical reaction to egg. IgE titres may help to determine 
      the potential risk of a reaction to eggs.
FAU - Benhamou, Avigael H
AU  - Benhamou AH
AD  - University Hospital of Geneva, Department of Paediatrics, Geneva, Switzerland.
FAU - Zamora, Samuel A
AU  - Zamora SA
FAU - Eigenmann, Philippe A
AU  - Eigenmann PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cooking
MH  - Egg Hypersensitivity/blood/*diagnosis/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunologic Tests
MH  - Infant
MH  - Male
MH  - Predictive Value of Tests
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2008/02/09 09:00
MHDA- 2008/04/23 09:00
CRDT- 2008/02/09 09:00
PHST- 2008/02/09 09:00 [pubmed]
PHST- 2008/04/23 09:00 [medline]
PHST- 2008/02/09 09:00 [entrez]
AID - 10.1111/j.1399-3038.2007.00602.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2008 Mar;19(2):173-9. doi: 
      10.1111/j.1399-3038.2007.00602.x.