PMID- 18258476
OWN - NLM
STAT- MEDLINE
DCOM- 20080429
LR  - 20220316
IS  - 1359-6101 (Print)
IS  - 1359-6101 (Linking)
VI  - 19
IP  - 1
DP  - 2008 Feb
TI  - Dendritic cells and cytokines in human inflammatory and autoimmune diseases.
PG  - 41-52
LID - 10.1016/j.cytogfr.2007.10.004 [doi]
AB  - Dendritic cells (DCs) produce cytokines and are susceptible to cytokine-mediated 
      activation. Thus, interaction of resting immature DCs with TLR ligands, for 
      example nucleic acids, or with microbes leads to a cascade of pro-inflammatory 
      cytokines and skewing of T cell responses. Conversely, several cytokines are able 
      to trigger DC activation (maturation) via autocrine, for example TNF and 
      plasmacytoid DCs, and paracrine, for example type I IFN and myeloid DCs, 
      pathways. By controlling DC activation, cytokines regulate immune homeostasis and 
      the balance between tolerance and immunity. The increased production and/or 
      bioavailability of cytokines and associated alterations in DC homeostasis have 
      been implicated in various human inflammatory and autoimmune diseases. Targeting 
      these cytokines with biological agents as already is the case with TNF and IL-1 
      represents a success of immunology and the coming years will expand the range of 
      cytokines as therapeutic targets in autoinflammatory and autoimmune pathology.
FAU - Blanco, Patrick
AU  - Blanco P
AD  - CHU Bordeaux, 33076 Bordeaux, France. patrick.blanco@chu-bordeaux.fr
FAU - Palucka, A Karolina
AU  - Palucka AK
FAU - Pascual, Virginia
AU  - Pascual V
FAU - Banchereau, Jacques
AU  - Banchereau J
LA  - eng
GR  - U19 AI057234-02/AI/NIAID NIH HHS/United States
GR  - P01 CA084512-01A10003/CA/NCI NIH HHS/United States
GR  - R01 AR050770-01/AR/NIAMS NIH HHS/United States
GR  - P01 CA084512/CA/NCI NIH HHS/United States
GR  - R01 AR050770/AR/NIAMS NIH HHS/United States
GR  - R01 CA078846-01A1/CA/NCI NIH HHS/United States
GR  - P50 AR054083-01/AR/NIAMS NIH HHS/United States
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
GR  - R0-1 AR050770-01/AR/NIAMS NIH HHS/United States
GR  - R01 CA078846/CA/NCI NIH HHS/United States
GR  - P50 AR054083/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Interferon Type I)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity/immunology
MH  - Cytokines/*physiology
MH  - Dendritic Cells/*physiology
MH  - HMGB1 Protein/physiology
MH  - Humans
MH  - Immune Tolerance/physiology
MH  - Inflammation/*immunology
MH  - Interferon Type I/physiology
MH  - Interferon-alpha/physiology
MH  - Interleukin-1/physiology
MH  - Interleukin-12/physiology
MH  - Interleukin-6/physiology
MH  - Toll-Like Receptors/drug effects
MH  - Tumor Necrosis Factor-alpha/physiology
PMC - PMC2413068
MID - NIHMS49760
EDAT- 2008/02/09 09:00
MHDA- 2008/04/30 09:00
PMCR- 2009/02/01
CRDT- 2008/02/09 09:00
PHST- 2008/02/09 09:00 [pubmed]
PHST- 2008/04/30 09:00 [medline]
PHST- 2008/02/09 09:00 [entrez]
PHST- 2009/02/01 00:00 [pmc-release]
AID - S1359-6101(07)00104-9 [pii]
AID - 10.1016/j.cytogfr.2007.10.004 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2008 Feb;19(1):41-52. doi: 
      10.1016/j.cytogfr.2007.10.004.